Innovative technology for stem cell survival and maintenance in 3D culture – 3D +

The major aim of this project is the perfection of an innovative 3D cell culture technology, that supports proliferation and development of various cell types.
The 3D cell culture technology permits a more realistic environment in comparison with that of traditionnal cell culturing, regarding caracteristics morphology and behavior in addition to intercellular interaction.

A collaboration realised with Pr Didier Le Cerf team (CNRS UMR 6270, Université de Rouen) conducted the implementation of innovative structure taking into consideration its new applications and interesting proporties.

This project already initiated and directed by Pr Jean-Pierre Vannier, is actually taken out of the laboratory by Elise Demange, a PhD student, motivated by the creation of a start up. The valorisation team of Rouen University has already leaded two studies : the first one is the patentability study founded by "Plasseraud" cabinet and the second one is the study of valorisation and potential performed by Eurobiobiz.
The state of art revealed that none of the established documents (i.e. publications, on going patents and published patents) described specifically neither the method of preparation of hyaluronic acid hydrogel nore the cell recuperation method particularly stem cell in the hydrogel.
The two patents are "on going" and in a state of finalisation, one regarding the hyaluronic acid preparation method before being used for cell culture, and the other one regarding cell recuperation for the latter scaffold (hyaluronic acid hydrogel).
The two patents are european and in english, and will be filed beginning of June 2010.

The valorisation structure will support Pr Jean-Pierre Vannier and Elise Demange in their first commercial position research. SEINARI incubator will be also solicit and a project will be present at the national concurrence for the creation of innovative start up in the division emergence. This support should give the possibility to realise position and technic / economic studies.