Emergence - Emergence

Phosphorus-containing dendrimers: innovating molecules for the treatment of Rheumatoid Arthritis – INNO-THER-RA

Submission summary

Our project aims at proposing a new therapy against Rheumatoid Arthritis (RA). RA is considered an auto-immune and inflammatory disease affecting 0.5% of the population in developed countries (300,000 cases in France). It is characterized by bone resorption, due to giant multinuclear cells called osteoclasts (OCs) which differentiate from monocytes, and by deformation of joints. Current therapies which stop the disease but failed to cure it are very expansive and present contra-indications regarding a third of patients. Our project relies on the observation that well-defined and innovating synthetic molecules, so-called phosphorylated dendrimers, can inhibit the formation of OCs and thus bone resorption in vitro. Moreover, these molecules activate human monocytes toward an anti-inflammatory phenotype. We have demonstrated this anti-inflammatory activity of phosphorylated dendrimers in vivo in a mouse model of spontaneous arthritis. An international pending patent has been filed in on the 1st of August 2008. Now, in order to promote our invention, we need to afford data regarding pharmacodynamics, pharmacokinetics and toxicology of phosphorylated dendrimers.
All together, the economic, societal and scientific points described above highlight phosphorylated dendrimers as promising therapeutic tools for the treatment of RA and other chronic inflammatory pathologies in which bone resorption takes place.

Project coordination

Rémy POUPOT (UNIVERSITE TOULOUSE III [PAUL SABATIER]) – remy.poupot@inserm.fr

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

UPS - JE2510 UNIVERSITE TOULOUSE III [PAUL SABATIER]
CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - DELEGATION REGIONALE MIDI-PYRENEES
UPS - CPTP UNIVERSITE TOULOUSE III [PAUL SABATIER]

Help of the ANR 152,002 euros
Beginning and duration of the scientific project: February 2011 - 18 Months

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