Prolactin receptor signaling as a major modulator of beta cell and adipocyte biology :pathophysiological impact on metabolism. – ADIPOBETAPROL

The pituitary lactogenic hormone prolactin and placental lactogens exert various physiological actions in humans and rodents, via their binding to the prolactin receptor (PRLR). Beside the role of PRLR in lactation and reproduction, accumulating evidence suggests that they are present and exert crucial impact on adipose tissues and endocrine pancreas, two major players of whole body energy balance involved in the pathophysiology of diabetes. We showed a dual contribution of the PRLR through insulin-like growth factor 2 (IGF-2) in the modulation of beta cell mass and function and of adipose tissue development. Given the impact of PRLR signaling in carbohydrate metabolism and lipid homeostasis, the main scope of our proposal is to determine the physiological and pathophysiological role of PRL in the context of diabetes. By complementary approaches, we aim to identify new PRL mediated-regulators using original cell lines, new recombinant mouse models and clinical investigations.