Synthèses, caractérisations et utilisations de nouveaux réactifs stanniques supportés sur liquides ioniques recyclables – RECYTIN

Organostannic derivatives are known for their strong toxicity and the current challenge consists in avoiding any contamination by stannic residues when these derivatives are used. As an example, usual procedures employing stannic compounds in industrial synthesis of pharmaceutical products prove completely prohibited, in spite of the fundamental synthetic advantages they can bring. In order to avoid this technological bolt, we propose to synthesize new reagents and catalysts based on tin supported on ionic liquids and to study their reactivity. Covalent binding of these species to the support must thus make it possible to avoid any rejection of toxic substrate according to a methodology similar to those already largely used for other types of organometallic derivatives. A new class of ionic liquids supported tin reagents will be obtained by preparation of the support, an imidazole derivative, then anchorage of tin (IV) derivatives on various supports either by substitution of a halogen or by fonctionnalisation of a terminal double bond. These new supported organotin reagents will be engaged in the Stille coupling. We will, then, evaluate the recycling of supported tin without loss of reactivity and will determine the rate of tin contamination of the end products.