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The mechanisms underlying the formation and development of neuronal assemblies – neuralAssembly
Across the entire brain, neural circuits exhibit remarkable diversity across species, in both macroscopic architecture and cellular composition. As our understanding of neural computations has advanced, neuroscientists have been able to identify common building blocks and overarching mechanisms oper
Mechanical-molecular interplay underlying the self-organized patterning of the early embryo. – ForcePattern
Mechanical forces play an essential role in embryonic development, most evidently as the drivers of morphogenesis, but also as short- and long-range signals contributing to self-organized patterning. Whereas the role of mechanics in cell fate specification has long been demonstrated in vitro, how m
Quinone biosynthesis, diversity, and evolution across the Tree of Life – ToLQuin
Isoprenoid quinones are lipids that shuttle electrons between enzymes of electron transport chains, thus playing a central role in cellular energy production. Quinones are structurally diverse, with differences in the quinone moiety modulating their redox potential. Low potential quinones are used p
revealing fundamental invariants and transitions of complex multiscale patient data: life-span study – AUDACITIES
Physical theories are based on stable mathematical structures, based on regularities and symmetries. In these theories, objects are defined and understood thanks to invariants and transformations preserving the invariants. These invariants allow the synthesis of physical laws, useful for making pred
Animals, humans, environment: the ANR is committed to One Health
,,The One Health approach is based on the interdependence of human health, animal health, and ecosystem health. Adopting this holistic perspective is essential for better anticipating, preventing, and managing health risks. On the occasion of the One Health Summit, taking place April 5–7 in Lyon, th
Fluid instabilities and active flows during vertebrate embryo body segmentation – Fidelio
One of the flourishing domains in modern developmental biology investigates the role of mechanical forces and biochemical signals in shaping embryonic tissues and driving the emergence of form. Somitogenesis in vertebrate embryos is a remarkable example, where a tissue—the presomitic mesoderm (PSM)—
Periodicity in Netrin-1 signalling activity during the cell cycle controls stem cell features – PerioNet
The integration of multiple signals dictates the emergence and properties of pluripotent stem cells (PSC) during mammalian development. Understanding the balance between self-renewal and differentiation in PSC is highly relevant for developmental and reproductive biology but also for regenerative me
Waste Water Monitoring System based on in-field Nuclear Magnetic Resonance – Wa2MOS
Perfluoroalkyl and polyfluoroalkyl substances, commonly known as PFAS or "forever pollutants," are synthetic organofluorine chemical compounds widely used in numerous everyday products, such as non-stick coatings, waterproofing agents, and firefighting foams. Their long-term accumulation and persist
Rescue of postnatal brain development in Coffin-Lowry Syndrome – RSK-ue
Coffin-Lowry syndrome (CLS) is a rare genetic disorder characterized by intellectual disability. To date, there is no preventive or curative treatment for this syndrome. CLS is caused by mutations in the Rsk2 gene, which encodes the RSK2 protein kinase. RSK2 acts at the end of the ERK/MAPK signaling
Quantum Fluids-of-LIGHt Turbulence in Semiconductor microcavities – Q-FLIGHTS
Quantum fluids are a remarkable class of physical systems where quantum properties emerge on a macroscopic scale. Examples like superconductivity, superfluidity, and Bose-Einstein condensation showcase the striking effects of macroscopic coherence in quantum fluids. When driven out of equilibrium, b
