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Anti-Bacterial Immune Regulation – Abir
Infections by intracellular bacterial pathogens of the genus Salmonella spp. and Listeria spp. remain leading causes of foodborne illnesses. For instance, typhoid fever, a disease caused by Salmonella typhi affects about 16 million people and causes 500,000 to 600,000 deaths each year. Listeria infe
Anti-Fungal Innate Immunity in C. elegans – FUN-EL
The oldest defence mechanisms, collectively called ‘innate immunity’, evolved millions of years ago, before modern animal species emerged. The most important elements of these defences have been conserved across time. One can therefore use simple models like C. elegans, which doesn’t pose any ethica
AntiMicrobial Agents from LIchen Associated bacteria – AMALIA
Antibiotic resistance (AR) and persistence of pathogenic microorganisms are emerging threats to human health, as the number of antibiotics effective against resistant bacteria is increasingly scarce. Microbe-host symbiotic interactions often depend on bioactive molecules with an antibiotic potential
Antibiotic Resistance: Coordinating Research at the Supra-national Level
The discovery of antibiotics constitutes one of the most crucial advances in the history of medicine. Their use has revolutionised the way we fight bacterial infections and significantly reduced the number of deaths they cause. The development of antibiotic resistance and, more broadly, anti-micr
Anticipating, deciphering, imicking molecular complexity of natural substances – ANTIDEPRIM
The project is structured in three «layers of knowledge« (cf title of the project) and aims to compare and analyze them in the era of «-omics« and megadata. The «field of possibilities« is explored by powerful anticipation tools invented in the consortium; biosynthetic pathways, results of evolution
Antifungal Resistance: From Surveillance to Treatment – AReST
Invasive fungal infections are an underestimated health problem, which is exacerbated by their difficult diagnosis and an increasing emergence of resistances to the few antifungals currently in use. Among the most common fungi in France and Germany causing systemic mycoses with high mortality rates
Antigen presenting cells in alloimmune response to factor VIII (FVIII): exploring innovative therapeutics through the molecular dissection of endocytic pathways – ERF8
Hemophilia A is a rare X chromosome-linked recessive disorder that concerns 1/5000 individual. Genetic abnormalities in the FVIII gene result in qualitative or quantitative defects in FVIII production. In its severe form, hemophilia A is a life-threatening, crippling hemorrhagic disease. Treatment o
AntimicrObial stainless-steel suRfacEs Grafted with ArylbeNzothiazole structures for fOod industry – OREGANO
The food industry faces the major challenge of guaranteeing optimal surface hygiene while improving operational efficiency. The OREGANO project aims to develop innovative metallic surfaces with a dual antimicrobial effect. This effect will be achieved through the covalent grafting of arylbenzothiazo
Antimicrobial peptides nanodelivery systems based on Aptamers/Mesoporous silica nanoparticles – ALES
The excessive use of antibiotics has led to emergence of bacteria strains, which are resistant to a range of antimicrobials, including first-choice agents for the treatment of humans. By 2050, the death toll caused by the antimicrobial resistance could exceed the one related to cancer and diabetes c
Antisense sequences delivery for therapeutic intervention on messenger RNAs – GENESPLICE
Up to 50% of disease-associated mutations in humans affect the pre-mRNA splicing and maturation processes, by inactivating splicing signals, creating cryptic ones or modifying binding sites for splicing regulators. They result in exon skipping, inclusion of cryptic exons or intron retention, and in
