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Decreasing ganglioside synthesis as a therapy for hereditary spastic paraplegia
1. Proof of concept : downregulating GM3 synthase in vivo using a viral vector<br />2. Test therapeutic efficacy of antisense oligonucleotides (ASO) targeting GM3 synthase in a mouse model of SPG11<br />3. Preparing translation of preclinical proof of concept into clinical trial
Integrating microbial METAbolism into CLOUD chemistry: from" omics" to a model
METACLOUD is focused on studying the ability of the cloud microbiome to metabolize single carbon (C1) compounds and integrate it into a model of atmospheric chemistry. Its originality is «omic« methods. For the moment these biological processes are not described in the models.
A-site Manganites for mAgNetoelectrics and mulTiferroics from extreme conditionS
The hypotheses underpinning this AMANTS project are 1) that a variety of novel A-site based Mn oxide perovskites and related phases can be recovered from high pressure synthesis, and that these new materials will have interesting and potentially useful properties. And 2) that the new playground of “hard-soft” synthesis has an important role on the new A-site Mn2+ materials by modifying their anion lattices.
Ring opening co-polymerization of succinic anhydride derivatives and epoxides from bio-based resources via organocatalysis
Considering the environnemental impact and the futur shortage of fossil ressources, the development of materials originated from renewable ressources has become a global concern. The main purpose of this project is to place organocatalysis in the service of ring opening polymerization, for the synthesis of polymers based on renewable resources.
Chiral Cyclic Alkyl Amino Carbenes in Asymmetric Catalysis
The CiCAAC project involves the development of a new class of chiral carbenic ligands and their associated complexes for asymmetric catalysis.
Quasi Cyclic Small Packet
The publication of 3GPP Release 15 in June 2018 paved the way for the new 5G air interface, making a new step towards the new generation of mobile networks. The work on the development of a new radio
An evolutionary perspective on meiotic kinetochore architecture and function in oocytes
The overarching goals of our project are to determine how kinetochores, the attachment sites for microtubules on chromosomes, are assembled, attached, correctly oriented and put under tension in oocyte meiosis. Using two distantly related organisms, namely C. elegans and mouse, we aim to determine how characteristics of the meiotic kinetochore bring about the specific segregation patterns in meiosis.
Toward Non-Invasive Ultrasound Surgery
Only 25% of patients with primary or secondary liver tumors are candidates for curative treatment. Focused ultrasound has the potential to be a new therapeutic option but major innovations are needed. The challenge of the TONUS project is to implement these breakthrough innovations and to demonstrate the feasibility, efficacy and preclinical safety of this new treatment in order to be able to start using it in clinically.
Data and Prior, Machine Learning and Control
We propose to combine machine learning and control theory for sequential decision-making of multiple agents. The project proposes fundamental contributions: adding stability to the algorithms of reinforcement learning; data driven methods for robust control; hybrid ML / CT methods for multi-horizon control and planning; decentralized control. The methodological contributions of this fundamental IA project will be applied to the robust control of UAV fleets
Complex and nonlinear fluids of light
CONFOcaL is a theoretical project aiming to explore the properties of disordered fluids of light. Fluids of light constitute novel and flexible systems of effectively interacting photons that exhibit many fascinating properties of quantum gases. This topic falls in line with a strong scientific activity in the field of cold atomic gases, but it addresses these questions from the original perspective of optics.
