Search
In vivo and ex vivo validation of MR tractography of brain white matter tracts – FIBRATLAS II-III
State of the art. Changes in brain white matter may serve as a biomarker for numerous neurological diseases. Diffusion Weighted Imaging (DWI) is a non-invasive MRI technique providing information on white matter tracts (tractography) by studying water diffusion. Despite being based on mathematical m
Immobilized-on-Metal Peptide Layer for Arterial NexT generation Stents – IMPLANTS
Metallic stents are widely used in endovascular treatment of coronary stenosis (balloon-expandable stents) and cerebral aneurysms (self-expandable flow diverters). In spite of the different design, both types of device are hampered by potentially life-threatening complications linked to the reaction
Microrobotic nasal endoscopy by OCT: impact of smell deficiency on neurodegenerative diseases – NEMRO
The scientific and technological challenges of the proposal include numerous aspects. This in terms of: 1) optimized medico-mechatronics design, precise, lightweight, biocompatible, non-invasive, 2) hybrid-actuated microrobotics device (2mm of diameter) ultra-precise, flexible with good dynamic and
Design and development of a self-powered, fine-tunable knee implant – EMERGE
Context The project EMERGE fits into the overall problem of postoperative complications following the total knee arthroplasty (the implantation of a total knee replacement). These complications resulting from various surgical and non-surgical factors may shorten the lifespan of this implant and co
Retinal Laser Microsurgery guided by OCT and adaptive optics – CLOVIS3D
Retinal laser photocoagulation is commonly used in ophtalmology to treat the macular edema. Macular edemas may result from various pathologies, the first of which is diabetic retinopathy, affecting one to two million people in France alone. The usual treatment for macular edema is a photocoagulation
Leadless cArdiac implants inclUding Reliable and robust piEzoelectric energy hArvesTing devices – LAUREAT
LAUREAT project aims at overcoming several technological and scientific barriers: long term reliability of piezoelectric materials/devices, aging effects over performances, defect mechanisms of piezoelectric materials/devices, design for reliability, reproducible manufacturing technology for materia
Devices and systems targeted towards augmented robotic radical prostatectomy #2 – DEPORRA2
Surgical treatment of prostate cancer (one of the first cause of mortality by cancer in men) is in mutation with the introduction of robotic systems in the operating room (such as the da Vinci® telesurgery system or the ViKY® endoscope holder). However, robot assisted procedures do not exploit endo-
Ultrasound-Mediated Targeted Drug Delivery – SOUNDELIVERY
ultrasound contrast agents (ACUs) consist of microscopic gas bubbles encapsulated and used for ultrasound imaging. They can also carry active agents and, selectively adhere to specific sites in the human body. Combined with the effect of sonoporation, this ability has the potential for targeted drug
REtinal Surgery systEm for Training – RESET
According to the world health organization, retinal diseases are responsible for at least 10 millions of blind people. They represent already 15% of the causes of visual impairment and are probably underestimated. Diabetic retinopathy is the major cause of blindness in developed countries before 50
Optimized transport mechanisms of bacteriophages for the development of antibacterial coatings – MAGENTA
Adhesion of micro-organisms, in particular bacteria, plays an important role in biofilms formation and the colonization of biotic or abiotic surfaces. These biofilms can be formed on any type of surfaces, and represent important financial losses e.g. in food and water treatment industries. Moreover,
Lensless endoscopy: Imaging deep in the living brain – LENIMBRA
A persistent challenge in two-photon excited fluorescence (2PEF) imaging is deep imaging in tissue. In particular, a challenge lies in recording neuronal activity with single-cell resolution deep in the living brain. 2PEF microscopy is a method of choice for imaging the activity of neurons but due t
HIGH SENSITIVITY SUPERCONDUCTOR RADIOFREQUENCY PROBES FOR MAGNETIC RESONANCE MICRO IMAGING – SupraSense
SupraSense is an experimental research proposal at the interface of physics and medicine. It aims at the realization of high sensitivity radiofrequency (RF, 1 to 400 MHz used for NMR) probes, dedicated to Micro - Magnetic Resonance Imaging (µIRM). The latter is an imaging technique with high sensiti
Elaboration of smart biomaterial to prevent pancreatic fistula after pancreatectomy – FP-BioPrev
Postoperative mortality of pancreatectomy is 5% and morbidity of this surgery is high with a complication rate around 50%. One of the most serious complications of pancreatectomy is the occurrence of pancreatic fistula (PF). A FP is a wound healing and sealing of intestinal anastomosis and leakage o
Aortic Aneurysm Damage and Rupture Prediction – AADaRP
The rupture of an aortic aneurysm, which is often lethal, is a biomechanical phenomenon that occurs when the wall stress state exceeds the local strength of the tissue. Current understanding of arterial rupture mechanisms is poor, as the physics taking place at the microscopic scale in collagenous s
Development of a Real Time Monitoring non invasive In Vivo Mass Spectrometry System for Diagnostic: REALITY'MS – REALITY'MS
The challenge of the SpiderMass project is to develop an instrument for allowing the analysis in-vivo and in real-time in the surgical room. This is a main issue with regards to the importance of the quality of the surgery on patient’s outcome and survival. Currently, none of the existing technologi
Creation of a bibliographic/bibliometric database including the main Health content in French (journals, encyclopedias, books) freely available on the Internet – BDBfr
The Web is a major source of information for Health professionals. Accessing and using this information may be difficult to French speaking persons as the English language is more and more overwhelmingly present in Health sciences. In documentary sources content and interfaces are mostly in English
Stroke is the leading cause of disability in adults. The annual incidence is 100 to 300/100 000. In 60 % of cases, patients retain sensory and/or motor sequelae at the upper limb. This results in a loss of autonomy in all activities of daily living such as dressing, bathing or feeding. Improving cap
Open Data maps: interactive, collaborative, and accessible for visually impaired people – AccessiMap
AccessiMap is a multidisciplinary and innovative project with elements of fundamental and applied research. Its goal is to improve access to maps for the visually impaired (VI), through the design of suitable non-visual interactions based on Open Data (e.g. OpenStreetMap). The project addresses diff
Quantitative Phase Imaging in Living Cell High-Content Microscopy – PhaseQuantHD
High content imaging is a rapidly evolving technique which makes quantitative analysis of multiple events in a population of cultured cells. The evolution with time is also studied. A new generation of fully automated systems acquires images entire cultured cell populations with multimodal quantitat
Coronary Flow Reserve Imaging without Tracers – COFLORES
Synopsis The present proposal aims at providing a reliable, fully non-invasive, quantitative and repeatable cardiac MRI method for assessing Myocardial Blood Flow in rest and stress conditions, i.e. Myocardial Blood Flow and Coronary Flow Reserve (CFR) in humans and small animals. It is designed to
High resolution functional imaging of neuronal activity by wave front shaping of ultra fast pulses – WaveFrontImag
Voltage and calcium imaging can revolutionise our understanding of how neuronal cells and circuits process and store information in the living brain. To explore the mechanisms underlying synaptic transmission, membrane potential and calcium transients must be measured from neuronal dendrites and spi