DS0404 - Innovation biomédicale

Design and development of a self-powered, fine-tunable knee implant – EMERGE

Submission summary

The project EMERGE fits into the overall problem of postoperative complications following the total knee arthroplasty (the implantation of a total knee replacement). These complications resulting from various surgical and non-surgical factors may shorten the lifespan of this implant and consequently lead to revision surgery. Given that the current designs of total knee replacement compensate for the absence of the anterior and posterior cruciate ligaments by their shapes more or less congruent, the stabilization functionality of the collateral ligaments can be ensured by the surgical technique. However, despite the fact that the cutting guides allow the surgeon to properly align the prosthetic components of total knee replacement with respect to the mechanical axis, there is no computerized system allowing him to perfectly balance the collateral ligaments as has been reported in several postoperative studies. Moreover, even if the collateral ligaments are perfectly balanced at the time of surgery, it is not necessary that the balance will remain perfect in the years following this surgery. This is due to the fact that the morphology of the patient including age, weight, and lifestyle will considerably change with time. Therefore, the functionality of total knee replacement becomes suboptimal; which may sometimes lead to a revision surgery (9% at 10 years, 16% at 15 years, and 22% at 20 years). These proportions will result in a considerable number of revision surgeries considering the increase in life expectancy on one hand, and the growing demand for this type of surgery from younger and active patients on the other hand.

To meet this issue, a new generation of knee implant, able to compensate for the variations of functionalities by its adjustable and adaptive shape, will be proposed. Developing such a self-powered implantable device involves ensuring its power supply and its control using embedded sensors. Innovative and multidisciplinary project aims to minimize the significant number of revision surgeries by implementing the first generation of dynamic implants.

Objective of this program
The goal of this program is to develop a new generation of instrumented knee implant comprising (1) an integrated power generator, (2) a power conditioning system (3) a telemetry system, and (4) an actuator for fin-tuning the implant shape in the postoperative period. A preclinical validation will be performed in order to validate the proof-of-concept. The ratio risk/benefit will be evaluated in a clinical study that is not part of this program in order to determine the delivered medical service.

Project coordination

Chafiaa Hamitouche (Laboratoire de Traitement de l'Information Médicale)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.


LaTIM / IMT TB Laboratoire de Traitement de l'Information Médicale
UM2-LIRMM Laboratoire d'Informatique, de Robotique et de Microélectronique de Montpellier

Help of the ANR 494,166 euros
Beginning and duration of the scientific project: November 2014 - 24 Months

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