DS0404 - Innovation biomédicale

Aortic Aneurysm Damage and Rupture Prediction – AADaRP

Submission summary

The rupture of an aortic aneurysm, which is often lethal, is a biomechanical phenomenon that occurs when the wall stress state exceeds the local strength of the tissue. Current understanding of arterial rupture mechanisms is poor, as the physics taking place at the microscopic scale in collagenous structures remains an open area of research. The interaction of the arterial constituents in the situation of mechanical load bearing, their impact on the mechanical properties and their role in arterial rupture are still open questions. This represents a significant limit for the use of numerical modelling approaches as a help for decision to the surgeons, as well as for the development of potential preventive treatments.
Understanding, modelling, and quantifying the micro-mechanisms which drive the mechanical response of such tissue and locally trigger rupture represents the most challenging and promising pathway towards predictive diagnosis and personalized care of aortic aneurysm.
To develop a more detailed and comprehensive understanding of aneurysmal rupture, the PI's group developed an original in vitro experiment enabling to detect, in advance, at the macro-scale, rupture-prone areas in bulging ascending thoracic aortic aneurysmal tissues. These state-of-the-art results indicate that rupture occurs at a localized strain concentration. Accordingly, the next step is to examine the details of the arterial microstructure in order to elucidate the underlying mechanisms controlling the rupture response.
Through the achievements of AADaRP, an original experimental approach will be developed using multi-photon confocal microscopy combined with in situ bulging test of these aneurysmal tissues. This will enable to observe the tissue’s microstructure up to rupture. Then the local mechanical state of the fibrous microstructure of the tissue, especially close to its rupture state, will be numerically reconstructed to establish quantitative micro-scale rupture criteria. Based on these investigations and collected data, AADaRP will then address micro-macro modelling to build clinically-relevant biomechanical risk assessment models.
The entire project will be completed through collaboration with medical doctors and engineers, experts in all required fields for the success of AADaRP, and used to working together in Saint-Etienne.
AADaRP is expected to open longed-for pathways for research in soft tissue mechanobiology which focuses on cell environment and to enable essential clinical applications for the quantitative assessment of AA rupture risk. It will significantly contribute to understanding fatal vascular events and improving cardiovascular treatments. It will provide a tremendous source of data and inspiration for subsequent applications and research by answering most fundamental questions on aortic aneurysm rupture behavior, enabling ground-breaking clinical changes to take place.

Project coordination

Pierre BADEL (Centre Ingénierie et Santé)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

CIS Centre Ingénierie et Santé

Help of the ANR 0 euros
Beginning and duration of the scientific project: September 2014 - 48 Months

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