Search
Lithium Associated Tubulo-Interstitial Nephropathy (LATIN): role of collecting duct cells proliferation – LATIN
Bipolar disorder is a common condition, affecting 1 to 4% of the population worldwide, and a serious illness because of the suicidal risk during depressive and manic episodes. The most effective treatment to date is Lithium Carbonate. This undisputed efficacy is counterbalanced by long-term side eff
Molecular pathophysiology of iron homeostasis during anemia and targeted intervention – MARINADE
Anemia, defined as a decreased quantity of circulating red blood cells, is a major source of morbidity and mortality affecting a-third of the worldwide population. As a functional component of erythrocytes hemoglobin, iron is essential for oxygen storage and transport. The liver-derived peptide hepc
Deciphering emphysema pathophysiology through an engineered 4D-lung organoid – LUMEN
Chronic Obstructive Pulmonary Disease (COPD) is a common respiratory disease mainly linked to prolonged tobacco use, with no curative treatment to date. It is often associated with emphysema, corresponding to destruction of the lung alveoli, which pathophysiology remains poorly understood. In this p
How DNA Damage Response contributes to Liver Metabolic Disorders – DNAFAT
Non-Alcoholic Fatty Liver Disease (NAFLD) is a major public health concern. Alarmingly, steatosis (NAFL) progresses pejoratively to Non-Alcoholic Steatohepatitis (NASH), which is considered as a growing worldwide epidemic threat, due to the absence of treatment. DNA-FAT consortium identified for the
Regulation and role of COMT in joint pain and osteoarthritis – COMT
The proposed study aims to investigate the role of catechol-O-methyltransferase (COMT) in osteoarthritis and related-pain. Together, the three partners (BioConnecT, NorDic and BioScar labs) will elucidate the relationship between COMT variants and the physiopathology of osteoarthritis (OA), a chro
Force-Velocity-Endurance relation in Animal Locomotion – FOVEAL
The FOVEAL project aims at developing a novel theoretical framework for understanding the muscle force production capacity as a function of time and contraction velocity during animal locomotion. This project rely on a multidisciplinary research team including specialists in applied mathematics, mus
Deciphering the liver/heart dialog in the sexual dimorphism of the cardiac diastolic function – LIMPID
Heart failure (HF) with preserved ejection fraction (HFpEF) is a leading cause of morbidity and mortality throughout the industrialized world. HFpEF, characterized by a diastolic dysfunction, is considered as the predominant form of HF and currently accounts for ~50 % of all HF. This is a multi-orga
Delineating cilia-mediated signaling network in muscle stem cells – STEMCIL
Life-long skeletal muscle function relies on maintenance and regeneration of myofibers through a finely regulated process. It begins with activation of normally quiescent muscle stem cells (MuSCs) and proceeds with formation of proliferating MuSCs that either differentiate to repair injured myofiber
Role of gut microbiota dysbiosis on the development of spondyloarthritis – MICROSPA
Relationship between gut microbiota and joint inflammation has remained scarcely studied until now. Our recent studies in spondyloarthritis (SPA) -high throughput sequencing of fecal samples from 350 patients and healthy controls - revealed intestinal dysbiosis specific for this disorder, characteri
Erythropoiesis at the crossroad of TGF-beta signaling, epigenetic and mitochondrial dynamics. – ZEBERY
Erythroid differentiation is an essential and continuous process leading to the production of red blood cells. Anemia is a major health problem in humans with ~6-8% of the world population carrying an allele that is deleterious for red blood cell function in a homozygous state. How production of RBC
The RUSH (retention using selective hooks) system: a chemical-genetic system for the in vivo manipulation of intercellular communication – VIVORUSH
Complex endocrine circuitries are used to modulate animal physiology. Signals are exchanged constantly between tissues to ensure proper development and adaptation. In particular, metabolism tuning is based on time-controlled release of trophic factors to regulate energy consumption, appetite, fat st
Deciphering the role of telomerase in the hypothalamic control of energy homeostasis – THALATEL
Cellular senescence has emerged as a causal factor in obesity-related inflammation and metabolic disorders. Importantly, obesity is associated with shortening of telomere length, which is a major inducer of senescence. However, the question still remains of whether telomere shortening contributes di
Targeting of SUMOylation by the gut microbiota and dampening of intestinal inflammation – SUMONING
The gut microbiota produces a wide variety of metabolites, which modulate intestinal cell activities and participate to human physiology. The effect of gut bacteria on SUMOylation, an essential ubiquitin-like modification in intestinal physiology, has only been investigated in the case of bacterial
Screening and targeting of cilia defects in chronic obstructive pulmonary disease – STarCilOPD
Chronic Obstructive Pulmonary Disease (COPD) will be the third cause of death worldwide in 2030. An irreversible alteration of lung function is the hallmark of this inflammatory pathology. COPD diagnosis is frequently delayed and current treatments are mainly symptomatic. At a cellular level, epithe
Investigating senescent cell fragmentation as a new contributor to aging and disease – SenFrag
Cellular senescence is a complex cellular program best known for its role in promoting tissue aging, damage and disease. Critically, the manipulation or elimination of senescent cells is emerging as having significant clinical potential in treating aging and age-associated diseases. However, there a
Regulation of Mpl signalling and myelofibrosis by the tyrosine phosphatases Shp1 and Shp2 (REMYS) – REMYS
Megakaryocytes (MKs) are large polyploid cells that produce platelets and play a pivotal role in maintaining the bone marrow (BM) microenvironment. Abnormal MK development and function can give rise to myeloproliferative neoplasms (MPN), thrombocythemia and associated myelofibrosis (MF) with increas
Purkinje system remodeling in life-threatening arrhythmias – PurkinjeNet
Sudden cardiac death (SCD) due to ventricular arrhythmias is a major cause of mortality in ischemic diseases and cardiomyopathies, accounting for up to 85% of cases. Often these arrhythmias originate in specialized cardiomyocytes called Purkinje cells, which form a thin network at the luminal side o
Unravelling the Luminal Progenitor-Inflammation-STAT5 Vicious Circle in Benign Prostate Hyperplasia – PROSTAT5
Benign prostate hyperplasia (BPH) is the most prevalent disease in the ageing male. This common urological condition is caused by the progressive, non-malignant enlargement of the prostate gland. BPH leads to lower urinary tract symptoms (LUTS) that can start to be observed around the age of 50. Th
Protein S in Sickle cell disease – PROSICK
Protein S (PS) is a physiological anticoagulant which has also been implicated in phagocytosis of phosphatidylserine-exposing cells through the activation of TAM receptors. As such, PS appears to be at the crossroads of major pathophysiological mechanisms of sickle cell disease (SCD). SCD is caused
Influence of microglia priming on the progression of tauopathy in animal model's of Alzheimer's disease – PriMicro
Activation of microglia plays a crucial role in Alzheimer's disease, as demonstrated by the increasing amount of identified genetic susceptibility factors that are specifically expressed by these cells. Several studies further suggest that amyloid plaques induce a microglial phenotype that contribut
Uncovering the role of microglia in Alzheimer pathology in a non-human primate – PrimAlz
Alzheimer's disease is linked to the cerebral accumulation of aggregated amyloid-? (A?) peptide that initiate a pathological cascade leading to fibrillar aggregation of tau protein, tau spreading and leading to synaptic alterations. Microglia are now established as key regulators of Alzheimer's dise
Pathological involvement of the Cannabinoid Receptor 1 (CB1) in Chronic Renal Diseases – PiCaRCRD
Chronic kidney disease (CKD) affects several millions of individuals worldwide and despite considerable efforts and research, few therapeutic options remain available. The cannabinoid-1 receptor (CB1R) has emerged as potential targets in both metabolic and non-metabolic CKD due to its pro-fibrotic a
Preeclampsia and cell membrane repair – PEMEMBREP
Placental dysfunction induces placental diseases. Among those, preeclampsia (PE) is prominent and induces hypertension in the mother as well as proteinuria, sometimes threatening the life of the mother and of the baby, as well as their present and future well-being. PE is often complicated by intra-
Neuro-Immune contribution of Toxoplasma gondii to the progression of Alzheimer's Disease pathology – NinTenDo
Alzheimer's disease (AD) is a multifactorial disease for which several molecular and functional abnormalities are now well known. Among these, neuronal excitotoxicity on neurons leads to synaptic loss and build-up of DNA double-strand breaks (DSB) that drive neurodegeneration and cognitive decline.
Functional insights into regulatory non-coding genetic variation associated with type 2 diabetes risk – NEXT-T2D
Type 2 diabetes (T2D) is a multifactorial polygenic disease characterised by the dysfunction of pancreatic islet cells in secreting insulin in response to the body’s needs. Although genome wide association studies (GWAS) have been successful in identifying > 300 loci associated with T2D risk, the m
Unravelling the role of microglia dysfunction in neurodevelopmental disorders – NewMic
Perinatal inflammation is a major environemantal rick factor of neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD). Inflammation-induced long-lasting activation and modification of microglia (MG) alters the programming of the developing brain leading to persistant social a
Role of microbiota-derived Extracellular vesicles on enteric Neurons connectivity, gut functions and behaviour in autism spectrum disorder – ExtraNeuro
Autism spectrum disorders (ASD) are neuro-developmental disorders characterized by a lack of social skills, impaired communication and repetitive behaviours. The pathophysiological processes are still largely unknown but are thought to result from both genetic and environmental factors. Beside behav
Deciphering the molecular pathophysiology of Imprinting Disorders using Multi-Omics in human cellular Models – ID-MOM
Parental genomic imprinting is an epigenetic process that results in the mono-allelic expression of ~130 human genes depending on their parental origin. This process is regulated through the methylation of specific loci called imprinting control regions (ICRs). Defects in ICR methylation (including
Involvement of LRRC8 channels in CRYSTALs-mediated INflammasome activation during rheumatic diseases – CRYSTAL-in
Deposition of urate and pyrophosphate crystals (MSU and CPP) in the joints are responsible for gout and chondrocalcinosis respectively. The inflammatory reactions induced in these pathologies are due to the activation of resident macrophages involved in the release cytokines including IL1?. The matu
Epigenetic Regulation of Secretome in Duchenne Muscular Dystrophy: role of the Histone Methyltransferase SETDB1 in TGFbeta-induced Fibrosis – EpiMuSe
By employing an efficient method to prepare skeletal myotubes from patient-specific induced pluripotent stem cells (iPSCs) and immortalized myoblasts, we study the molecular mechanisms underlying the TGF?-induced fibrosis in Duchenne Muscular Dystrophy (DMD). Moreover, the signaling pathways control
Biological relevance of the dynamic ionic selectivity – IONIC
Background potassium channels play a key role in regulating cell physiology. Their high ionic selectivity for potassium ions was thought to be static, as its alteration by genetic mutations causes serious disorders such as ataxia, cardiac arrhythmias and adrenal adenomas. We challenged this dogma by
C4BPA, a new player in venous thromboembolism and complement system interactions – ComplementVTE
Venous thromboembolism (VTE), which encompasses deep venous thrombosis (DVT) and pulmonary embolism (PE), is the third leading cause of cardiovascular death after myocardial infarction and stroke. VTE is a frequent disease, 1 to 2 per 1000 per year, associated with long term complications affecting
STRUCTURE & FUNCTION OF C9ORF72 IN AMYOTROPHIC LATERAL SCLEROSIS, FROM PROTEIN STRUCTURE TO iPS CELL AND ANIMAL MODELS. – C9-StrucFonc
Amyotrophic Lateral Sclerosis (ALS) is the third most common neurodegenerative disease worldwide. This disease is characterized by degeneration of both upper and lower motor neurons leading to muscle paralysis and death of the patients in 2 to 5 years after age of onset. There is currently no treatm
B and T cell dialogue in multiple sclerosis physiopathology – BaT-MS
Multiple Sclerosis (MS) is an autoimmune chronic disease of the central nervous system affecting more than 2 million people worldwide. Ninety percent of the patients first develop a form called relapsing remitting MS (RRMS), which is considered acutely inflammatory. But, more than half of these pati
The cystine-TGFb balance controls macrophage activation and function in pancreatic islets – MATIS
The pancreatic islets are key micro-organs of the endocrine system that allow the maintenance of glycemic control through hormone secretion, mainly beta cell-derived insulin. Increasing evidence suggests a role of the immune system to finely tune metabolic homeostasis. As such, macrophages residing
Multi-dimensional organisation of signalling dynamics encoded by Gonadotrophin receptors – MOSDER
The physiology of reproduction is controlled by the action of two pituitary hormones, the follicle-stimulating hormone (FSH) and the luteinizing hormone (LH), on their cognate G protein-coupled receptors, FSHR and LHR, expressed at the cell surface of gonad cells. While the Gs protein-mediated signa
Study of SHP2-driven myelomonocytic lineage defects and contribution in age-related diseases – MeSSAGE
This project aims to decipher how myelomonocytic lineage defects drives Noonan syndrome (NS) clinical traits. The latter being reminiscent of age-related disorders, this study will unravel new determinants of age-related diseases as potent therapeutic targets. NS is mainly caused by activating mut
Deciphering how the interplay between dysbiosis and MAIT cells impacts skin repair – IMMUNESTA
Barrier sites are colonized with microbiota and are populated by innate and adaptive immune cells. Host immune system is involved in constant dialogue with commensal microorganisms while preventing pathogen entry. This interplay becomes critical during chronic wounds, which is correlated with persis
Role of ALPK1 in intestinal homeostasis – GUT-ALPK1
The human gut is colonized by trillions of microbes that constitute the microbiota and exert diverse functions often associated with beneficial physiological effects for their host. The vast repertoire of microbiota-derived molecules has an overall beneficial impact on the organism by maintaining th
Galectin3-CD146/MCAM interactions in the physiopathology of heart disease following Acute Kidney Injury – GalCAM-AKI
The aim of our proposal is to investigate the roles and interactions between Gal3 and CD146 in the cross-talk between the kidney and the heart after acute kidney injury (AKI). Our proposal lies on preclinical and clinical recently published data and preliminary studies, as we have previously reporte
Role of MAIT cells in the pathophysiology of pulmonary fibrosis. – FIBROMAIT
Fibrotic interstitial lung diseases are a diverse group of chronic and progressive respiratory disorders, with idiopathic pulmonary fibrosis being the most common member. Evidence gleaned from animal modeling and human studies suggests that innate and adaptive immune processes can orchestrate existi
SEIZURES ACCELERATE AGE-RELATED NEURODEGENERATION – EpiNeurAge
A pathological interplay between seizures and age-dependent neurodegeneration has been clinically reported and is debated. The occurrence of seizures is more likely to provoke cognitive dysfunctions in older vs. younger patients. Subjects with temporal lobe epilepsy (TLE) can present brain amyloidog
Upregulated Epithelial Proteases Fuel Biofilm Dysbiosis In Inflammatory Bowel Diseases – dysBIOFILM
There is no cure for millions of patients worldwide suffering from Inflammatory Bowel Disease (IBD), new therapeutic strategies are thus sorely needed. Over the past years, we have revealed that the intestinal epithelium constitutively secretes active thrombin and elastase into the intestinal lumen.
Elucidating pathogenic mechanisms involved in MFN2 associated neuropathies to develop diagnostic and therapeutic approaches – DynaMitoPathO
Mitochondria play a central role in cellular energy metabolism, as they produce most of the cellular ATP through the phosphorylating oxidation system (OXPHOS). Mitochondrial dysfunctions are responsible for a large number of diseases and are also involved in ageing and neurodegenerative diseases. Wi
A new pathway for reducing liver lipotoxicity bridging non-alcoholic steatohepatitis and atherosclerosis in type 2 diabetes – DETOXING
Nonalcoholic fatty liver disease (NAFLD) is an increasing chronic liver pathology affecting around 25% of the general population in Western countries. NAFLD is a continuum of pathological states ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) which can progress to fibrosis, cir
Role of Carabin in the progression of renal disease – Carabin
Chronic Kidney Disease (CKD) is a major burden of public health affecting millions of people around the world. Since so far there is no treatment against CKD, there is an urge to identify novel specific therapeutic targets to prevent CKD progression. X is an important modulator of renal function
Are megakaryocyte podosomes relevant targets in thrombocytopenia? – MegaPod
Background. Thrombocytopenia is defined as an abnormally low blood platelet count, exposing patients at high risks of hemorrhages. It is a common clinical problem in chemotherapy-treated cancer patients with varying incidence, severity and duration. Platelet are produced by megakaryocytes (MK) in th
Defining the role of glucocorticoids signaling in aging and age-related metabolic disorders – GLUCAge
Aging is a progressive physiological decline that predisposes individuals to age-related pathologies such as cardiometabolic diseases, leading causes of death in Europe. Loss of adaptation to various stresses, including metabolic stresses, emerged as both a hallmark and a driver of the aging process
Therapeutic role of CD44 in alcoholic liver diseases: from bone marrow myelopoiesis to liver inflammation – MYELASH
Alcoholic liver diseases (ALD) are the most prevalent causes of advanced liver disease in Europe and major drivers of liver-related morbidity and mortality. Chronic inflammation (ASH) is the progressive form of ALD and no pharmacological treatment is yet available. Our unpublished results showed tha
Control of energy metabolism by thyroid hormone in the hypothalamus – HYPOTHYRO
A better understanding of the brain mechanisms that control food intake and energy metabolism would help to face the worldwide obesity epidemic. Thyroid hormone is a key regulator of the hypothalamus control of energy metabolism. The mechanisms by which it controls both the secretion of neuropeptide
Cholesterol trafficking in cardiovascular diseases – TRAFIC
Intracellular cholesterol trafficking is essential for the maintenance of vascular integrity. However, the mechanisms by which cholesterol is transported into the cell are poorly understood. Recently, we showed that a ligand of Wnt signaling, Wnt5a, inhibits intracellular cholesterol accumulation in
Unravelling the Metabolic Regulation of Myonuclear Accretion – Myo-Add
Skeletal muscle function is supported by the excitability and contractility of the myofibers, which are highly metabolically active syncytia composed of hundreds of post-mitotic nuclei. Due to the post-mitotic nature of myofibers, muscle stem cells (MuSCs) are essential for adult muscle maintenance.
Role of brain-invading hemocytes and reactive glial cells in inflammatory responses triggered by neurodegenerative conditions in Drosophila – Hemo-Park
The immune system allows us to respond to external/internal insults. Moreover, through their ability to reach all tissues, immune cells are also involved in metabolic, neurodegenerative and autoimmune diseases, making them potential therapeutic targets. Parkinson’s disease (PD) is characterized by t
Senolysis in Langerhans Cell Histiocytosis – Sen-LCH
Langerhans Cell Histiocytosis (LCH) is a rare disease that mostly affects children but can be present at any age in life. The disease is characterized by an accumulation of mononuclear phagocytes, associated with a dense inflammatory infiltrate. A mutation of the MAP kinase pathway is systematically
Uncovering a new regulatory axis driven by TSLP in pathogenesis of inflammatory skin diseases – nRegSKIN
The skin is the body’s primary barrier against physical insults and microbial pathogens. Dysregulated immune responses at skin surface lead to inflammatory disorders such as atopic dermatitis (AD), which is associated to allergies and increased susceptibility for colonization or infection by microbe
Better understanding the pathophysiology of ischemic stroke using in vivo imaging approaches in awake animals: how to improve translation to clinic – THRONE
Therapeutic approaches aim to restore cerebral blood flow (CBF) with the endovascular thrombectomy enlarging the narrow therapeutic window of fibrinolysis from 4.5 hours to up to 6-24 hours, opening avenues for the development of new strategies to protect or repair the brain. However, in the last de
Physiological role of the primary cilium-autophagy axis in brain and vascular system aging – CILIOPHAGING
The cardiovascular system and the brain are dramatically affected during aging, leading to an increased risk of atherosclerosis and cognitive deficits. The medical and societal consequences of these alterations illustrate the importance of identifying the cellular mechanisms involved in neuronal and
Bioinspired Strategy To fight muscle atROphy : targetiNg the BMP/TGF-beta balance – B-STRONG
The B-STRONG project aims to provide new weapons in the fight against human muscle atrophy, a major public health problem. Indeed, the loss of muscle is associated with a reduction in the autonomy of patients (sedentary, malnourished, elderly, or suffering from cachexia) and with the development of
Retinoic acid and differentiation of gametes – ARDIGAM
In the mammalian testis, sustained spermatogenesis relies on spermatogonia (SG) stem cells. Their progeny either remain as stem SG (for self-renewal) or they proliferate as distinct populations of SG progenitors, and differentiate. Later, differentiated SG enter meiosis to achieve genetic recombinat
Glucose homeostasis alteration implicates a novel hypothalamic inflammatory pathway. – NeuroInflamIR
The mediobasal hypothalamus (MBH) plays a crucial role in sensing and collecting metabolic information carried by the bloodstream to regulate energy homeostasis by adequately responding to body needs. Alteration in the communication between the MBH and the periphery mostly resulting from the inappro
Inflammatory reflex-mediated control of phagocytes mobilization and function – KEVINplus
The cholinergic anti-inflammatory pathway of the inflammatory reflex has been shown to reduce local and splenic cytokine production and control inflammation in a variety of affections. The role of metabolic changes, alterations of monocyte mobilization, and polarization of monocyte-derived macrophag
Role of Trp and Phe gut-dependent Microbiota Metabolites in Atherosclerosis – MIMEA
The prevalence of Western diet-induced metabolic syndrome is booming contributing to persist increase of cardiovascular diseases (CVD), including atherosclerosis. Many patients with obesity suffer from adverse metabolic complications and associated atherosclerosis, whereas other remain metabolically
Mechanistic insights into oxidation-driven actin dynamics in platelet physiology – ACTOMIC
Actin dynamics plays a long-described and critical role in platelet physiology, but how, mechanistically, this is achieved and regulated remains an important open question. Actin filament networks constantly assemble and disassemble via various actin-binding proteins but also via post-translational
Mechanical Stretch Sensor Machinery and Relaxation of Human Cardiomyocytes – MASTERMIND
This project focuses on regulators of the mechanical stretch-sensing machinery in the human hearts. We aim to better define their contribution to the resistance of human cardiac myocytes to diastolic stretch. The mechanical response to stretch of the myocardium is a critical determinant of cardiac p
Targeting the Adapted colonic Microbiota for a better recovery after Intestinal Resection – AdMIR
Short Bowel Syndrome (SBS) results from an extensive intestinal resection and is the leading cause of intestinal failure. In addition to parenteral nutrition, an effective pharmacological treatment with a great heterogeneity of response in patients with SBS is used today. This very expensive treatme
A novel druggable pathway of chronic kidney disease – STOP-CKD
Chronic kidney disease (CKD), a major socioeconomic worldwide public health burden, is characterized by a progressive decline in renal function to end stage renal disease that can occur irrespective of the cause of the renal damage once a critical number of nephrons has been lost. Understanding the
PathophySiological impact of Inflammasome COntrol by PAK-kinases in psoriasis – PSICOPAK
By affecting more than 3% of adults in the human population, psoriasis is one of the most common skin diseases. Evidence of genetic predisposition has emerged with the association of inflammasome members NLRP1 and NLRP3 polymorphisms with higher risk of psoriasis. In addition, RhoGTPases dysregulati
Prevent transplant vasculopathy by targeting inflammation in the vascular smooth muscle – OPTIMISM
Transplant vasculopathy (TV) is a frequent and deleterious chronic complication after organ transplant. Despite progress in the management of transplanted patients, TV remains an unmet medical need. TV is characterized by an obstruction of intra-graft arteries, due to the formation of a neointima co
Study of the role of parkin transcriptional function in neuroplasticity and memory formation in Alzheimer's disease – AlzParking
The etiological trigger of Alzheimer’s disease (AD) remains to be identified. Among various hypothesis, the amyloid cascade has been widely studied but outcomes of clinical trials centered around the amyloid peptide have been disappointing. Our project stands outside this mainstream view. We postula
Molecular mechanisms controlling cytokine secretion during macrophage-mediated cardiac repair – CYTOCARE
Cardiovascular diseases and myocardial infarction in particular are the leading cause of premature mortality worldwide. While inflammation is an essential aspect of cardiac repair, it can precipitate heart failure when excessive in intensity or duration. Cardiac resident macrophages (CRM) play an in
Establishment of the immune-brain communication channel at the choroid plexus and its role in brain development – DevoCP
Development of a complex organism is a fast-paced process, which follows a set and precisely timed trajectory; deviation of one element during critical time windows can induce an aberrant formation of another with life-long consequences for the host. For example, perturbation in microbial colonizati
Role of Cholesterol accumulation in White Adipose Tissue dysfunction – ChoWAT
White adipose tissue dysfunction is central to the development of obesity-associated complications such as type 2 diabetes, non-alcoholic fatty liver disease and cardiovascular diseases. Despite the importance of this tissue, little is known about the early molecular determinants contributing to the
Role of the Receptor for Advanced Glycation end products (RAGE) and therapeutic impact of its Inhibition in Renal Aging – RAG-IREA
Through its impact on the increasing incidence of chronic kidney disease and the insufficient lifespan of renal transplants, renal aging has become a major public health problem. Vascular injury in the kidney is crucial in this process, as it leads to glomerular ischemia and fibrosis. While evidence
Deciphering HEArt-liVEr commuNication in nonalcohoLic fattY liver disease – HEAVENLY
Nonalcoholic fatty liver disease (NAFLD) is a major public health issue and an independent risk factor for myocardial infarction (MI) in epidemiological studies. Post-MI cardiac repair conditions patient outcome. Extracellular vesicles (EVs) are vectors of information between organs, found more abun
The network of ‘Chameleon’ thyrotrophs: a hidden unit of thyroid control – Chameleon
Thyroid hormone (TH) dysregulation is one of the most prevalent endocrine defects in humans, with a much higher occurrence in women than in men. Although circulating TSH is used to diagnose thyroid disorders, the functioning of TSH-secreting thyrotrophs (the rarest endocrine cells in the pituitary g
Role of mucosal immune cell-derived opioids in the regulation of basal sensory neuronal activity and its relevance in IBS patients – NOCICEPOP
Irritable bowel syndrome (IBS) is a frequent disorder characterized by visceral pain without established biological markers. The low efficacy of the therapies often leads IBS patients to seek more effective pain killers such as opioids which misuse has becoming a public health problem. In this conte
Modeling neurodevelopmental disorders using induced stem cells and cerebral organoids: the example of Mediator-related disorders – NDevCerebrOids
Neurodevelopmental disorders (NDDs) are child related diseases that include intellectual deficiency (ID), autism spectrum disorders (ASD) and epilepsy. Their molecular diagnosis has been considerably improved in the recent years. However, appropriate experimental models for functional studies are st