CE14 - Physiologie et physiopathologie

Targeting the Adapted colonic Microbiota for a better recovery after Intestinal Resection – AdMIR

Submission summary

Short Bowel Syndrome (SBS) results from an extensive intestinal resection and is the leading cause of intestinal failure. In addition to parenteral nutrition, an effective pharmacological treatment with a great heterogeneity of response in patients with SBS is used today. This very expensive treatment ( 250,000€/patient/year) prompts the search for other therapeutic targets.
Our hypothesis is that the specific microbiota or "lactobiota» of subjects with SBS is a potential reservoir of target signals contributing to the improvement of intestinal absorption capacities. The objective of the project is to study the role of this particular microbiota by identifying the signal factors improving intestinal absorption in SBS.
The perspectives are to identify bacterial species and / or metabolites from this « lactobiota » that could serve as targets to develop therapeutic strategies for the management of patients with SBS.

Project coordination

Johanne Le Beyec Le Bihan (Centre de recherche sur l'inflammation)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

CRI Centre de recherche sur l'inflammation
MICALIS MICrobiologie de l'ALImentation au service de la Santé
DMU BioGeM DMU APHP.Sorbonne : Biologie et Génomique Médicales

Help of the ANR 435,003 euros
Beginning and duration of the scientific project: September 2022 - 42 Months

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