Regulation and role of COMT in joint pain and osteoarthritis – COMT
The proposed study aims to investigate the role of catechol-O-methyltransferase (COMT) in osteoarthritis and related-pain. Together,
the three partners (BioConnecT, NorDic and BioScar labs) will elucidate the relationship between COMT variants and the
physiopathology of osteoarthritis (OA), a chronic and multifactorial disease linked to aging characterized by alteration of joint tissues
and pain. Indeed, whereas it is well-known that COMT variants are associated to OA-related pain, the role of COMT during
osteoarthritis and mechanisms responsible for OA-related pain are still totally unknown, whereas pain is the main reason for
consulting doctor and taking medications by OA patients. In this context, the objectives of this collaborative project are: i) to
elucidate the role of COMT in joint tissues; ii) to investigate the cellular and molecular mechanisms by which COMT variants affect
OA-related pain.
Project coordination
Catherine BAUGE (Université de Caen Normandie)
The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.
Partner
BIOCONNECT Université de Caen Normandie
NorDiC Neuroendocrine EndOcrine and GeRminal DIfferentiation and Communication
BIOSCAR Biologie de l'os et du cartilage: régulations et ciblage thérapeutique
Help of the ANR 552,570 euros
Beginning and duration of the scientific project:
January 2023
- 48 Months
