Search
A very-low-irradiating localization device for interventional radiology – NEWLOC
Interventional radiology (IR) procedures expose the staff (and of course also the patient) to ionizing radiations (up to 60 minutes of irradiation during complex but classical procedures). More than 500,000 IR procedures are performed each year in France. Although the progresses of fluoroscopy have
Computer Assisted Map Design for Visually Impaired People – ACTIVmap
The production of maps accessible to people with visual impairments (PVIs) is nowadays a predominantly traditional practice, mastered by professionals in document adaptation, and essentially available for locomotion instructors. Access to such representations for people with visual disabilities is
INNOvations in elastography to quantify Viscosity and ANisotropy of muscle – INNOVAN
Ultrasound (US) shear wave elastography (SWE) has become popular in both basic and clinical sciences to measure the localized mechanical properties of biological tissues non-invasively. As such, SWE demonstrated potential for diagnosis of various pathologies in which tissue stiffness is altered (e.g
Dynamic Sensor for Nano Biomarker – DYNABIO
Heart failure is a major public health problem affecting 23 million people worldwide. Most of patients must be frequently monitored. Acute decompensated Heart Failure, defined as “gradual or rapid change in heart failure signs and symptoms resulting in a need for urgent therapy”, constitutes the mai
Optical coherence tomography for REtinal Organoid imaging – OREO
Objective : To enable non invasive live imaging of retinal organoids with automated label free cell classification Research hypothesis : We can detect drug action on the same organoid before and after treatment Scientific and technical barriers to be lifted ? Current practice involves sacrificin
cOnception of bioresorbable self-rolled Patchs for the local trEatment of inflammatioN induced in the coloN after irradiation – OPENN
Pelvic cancers are among the most frequently diagnosed cancers worldwide. Radiotherapy (RT) plays a growing place in the management of malignant pelvic diseases. Even though great advances have been made in RT delivery techniques, radiation exposure of significant volumes of normal bowel persists, i
A new medical device to reduce the urinary lithiasis recurrence – URITRACK
The recurrence of the kidney stones (or urinary lithiasis) increases in all industrialized countries implying an increasing cost for healthcare systems. In this project, we propose to reduce it by developing a new connected auto-test monitoring the urinary composition. This device is composed of two
Microfluidic sorting system for bioprospecting new antibiotics – DEINODROP
Antimicrobial molecules play a major role in modern medicine but resistance is rising and is becoming a major threat. It is therefore crucial that we find new antibiotics in the coming years. The objective of this project is to develop a breakthrough technology using droplet microfluidics for the sc
iReCHeCk - A Robotic Handwriting Companion – iReCHeCk
Handwriting disorders (termed dysgraphia) are a far from a singular problem as nearly 6% of children between 5 and 11 years in France is considered dysgraphic. Moreover, research highlights the fundamental importance to detect and remediate these handwriting difficulties as soon as possible in child
Biomimetic liver-on-chip platform – MIMLIVERonChip
Many molecules dedicated to therapy are nowadays lately removed from the pipeline of drug discovery, in the clinical phases, because their toxicity or lack of efficacy has not been evidenced in preclinical studies. Researchers and pharmaceutical companies outline the critical need in the development
Ultrasensitive molecular magnetic resonance imaging to unmask intestinal inflammation – MAD-GUT
Inflammatory bowel disease (IBD) is the second most common chronic inflammatory disease worldwide and its prevalence has been increasing over the past decades in both adult and pediatric populations. Crohn’s disease and ulcerative colitis are the two principal subtypes of IBD and involve chronic im
Biomechanical cost quantification for wheelchair accessible cities – CapaCITIES
The manual wheelchair (MWC) is currently the most efficient device to restore locomotion when lower limb functions are, temporarily or definitively, impaired. However, MWC locomotion is a strenuous form of ambulation for the musculoskeletal system as the upper-limbs of the manual wheelchair user (MW
Toward Non-Invasive Ultrasound Surgery – TONUS
There are two main forms of liver tumors: primary hepatic cancer (cancer that starts in the liver, mainly hepatocellular carcinoma) and liver metastases from other tumors, mainly of the gastrointestinal tract (colon or rectum). In 2017, approximately 63,400 new cases of primary liver cancer were rep
Multiphoton endomicroscopy of atherosclerotic plaques – MEAP
MEAP project is about developing a fiber-optic catheter able to accurately detect through intravascular optical imaging vulnerable plaques of coronary atherosclerosis that are among the leading causes of death in the developed countries. Instable atheromatous plaques contain i) a large lipidic necro
Video-based analysis of autism behavior – ACTIVIS
In this project, we seek to early diagnose Autistic Spectrum Disorders (ASD), through automated video analysis. In this domain, few reliable solutions exist except off-line human expert analysis. For this purpose, we propose to develop a video interpretation platform allowing both the detection, by
Real-time multiparametric monitoring of oxidative stress status during embryo development by implementing high-performances electrochemical microdevices – EmbryoElecSense
In western developed countries, about 3% of births proceed from assisted reproductive technologies, most of them involving in vitro culture of the embryos. It was recently shown that oxidative stress, related to reactive oxygen (ROS) and reactive nitrogen (RNS) species in the culture medium, are maj
Development of Ultra-Fast MRI relaxation time measurements: Application in Image Guided Therapy – FastRelaxMRI
Several issues prevent the routine applications of MR mapping sequences. The major problem is the long acquisition time. Some techniques enable to obtain values rapidly, but at the expense of accuracy. In addition, the current mapping sequences are not applicable on every organs of the human body (
Hearing Restoration using focused ultrasound neurostimulation – HEAR-US
Cochlear implants bypass the malfunctioning auditory periphery of profoundly-deaf people to electrically stimulate their auditory nerve. Although many implant listeners can follow auditory-only conversations in quiet environments, their speech recognition performances are much poorer in real-life sc
pH Observation of Extracellular Fluid by NMR Involving Xenon – PHOENIX
Extracellular pH is determined by the net flux of acid and base into and out of the extracellular fluid; it provides crucial clues on the metabolism of living organisms. On the other hand, the control of pH is critical for the maintenance and regulation of organ and cell function, as is evident from
Development of a “scintronic" crystal for very fast timing gamma ray imaging applications – ClearMind
Recently, the development of new types of ultra-fast compact photo-detectors has improved the coincidence time resolution (CTR) of scintillation spectrometric chains below 100 ps (FWHM). These detectors consist of fast, thin scintillators, typically LSO, LYSO, LaBr3 or CeBr3 optically coupled to SiP
Long-term multi-dimensional neural probes for electrochemical detection of biomarkers in brain disorders – 3-DBrain
Neural prostheses offer promising perspectives to restore motor functions and communication capabilities in patients suffering from severe paralysis or neurodegenerative diseases. These approaches require the use of implanted electrodes offering the possibility to simulate or record brain activity w
Concomitant IDentification, Antibiotic REsistance characterization and Virulence evaluation of bacteria using adaptive targeted mass spectrometry – IDAREV
MALDI-TOF mass spectrometry has revolutionized pathogen identification by shortening this step by 24h compared to traditional biochemical tests. In contrast, the antibiotic therapy choice remains largely driven by conventional antibiotic susceptibility testing, hence with a delay of 18-24h after ID.
robotization of cochlear implant – ROBOCOP
According to the statistic of World Health Organization, over 5% of the world’s population, i.e., 360 million people, has disabling hearing loss. Cochlear implant surgery can be used for profoundly deafened patient, for whom hearing aids are not satisfactory, and it is regarded as one of the best op
Open resources and methodologies for the detection of drug-drug interaction in clinical data warehouses – REMIAMES
The existence of drug interactions in prescriptions is a risk for the patient and a reflection of improvable practices. These problems have already been quantified by studies on health care data. Nevertheless, to be credible and reproducible, these studies must have a rigorous methodology. Indeed, t
High resolution CARdiac MRI-thermometry on a clinical scanner using intracardiac COils – CARCOI
Atrial Fibrillation (AF) affects 750 000 people in France and is expected to increase 2.5 fold by 2050. In patients presenting persistent AF, the extent and locations of the arrhythmogenic substrate are highly variable. The success rate of catheter-based radiofrequency ablation procedures is in this
Integrated platform for functional monitoring of 3D engineered brain-tissue for fundamental research and drug screening – 3DNeuroChip
Integrated platform for functional monitoring of 3D engineered brain-tissue for fundamental research and drug screening. Neural disorders are affecting more than 10% of the world population (WHO 2016). Identifying therapeutic solutions to these diseases has become the prime societal interest. H
A new biphasic microgel as lipoxin delivery system for tissue engineering – BILIPOX
1. WP 1: To prepare and analyze BPMG of Si-HPMC as LXA4 delivery system in vitro 2. WP 2: To study the effect of LXA4-BPMGs on macrophage phenotype and under simulated in vitro inflammatory condition 3. WP 3: to assess the effect of LXA4-BPMGs in preclinical models of inflammation - We have develo
Droplet-assisted ultrasound for brain therapy using CMUT technology – DROPMUT
Rett syndrome (RTT) is a severe neurological disorder with an incidence of 1 in about 15,000, which accounts for up to 10% of severe intellectual disability of genetic origin in women. Current treatments aim to slow the loss of abilities and allow patients to live several dozens of years. RTT is cau
A double microscope/endoscope for the holographic manipulation of deep visual circuits – 2MEnHoloMD
Vision is the primary sense humans use to evaluate their surroundings and guide their behaviour. All forms of visual impairments have therefore a major negative impact on the life of affected subjects. Indeed, loss of eyesight is perceived by many people as one of the worst illness that could happen