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Spin chirality is an emergent quantum property that has been proposed for information encoding in quantum information processing applications. "Spin-chirality qubits" promise to be immune to magnetic noise, e.g. deriving d from magnetic nuclei in their matrix. The appearance of this property is clos

Crystallization underpins essential processes in our everyday life, creating exceptional materials. Control of crystallization outcome is paramount for polymorphic solids because each polymorph is potentially a “new” material with unique properties. Crystallization in confinement has emerged as a pr

Polonium, discovered by Marie and Pierre Curie in 1898, has received increasing attention due to its pronounced toxicity and prevalence in environmental matrices around historic uranium mining sites. In addition, its predicted significant production in lead-bismuth cooled fast neutron reactors impli

Synucleinopathies are characterized by the accumulation of a-Synuclein fibrils in tissues. Fibril precursors are misfolded proteins that can exist as different structurally distinct strains, potentially associated to different diseases. Real time quaking induced conversion (RT-QuIC) is an efficient

Operando NMR is a powerful technique for atomic-level characterization of the operating mechanisms and limitations of rechargeable batteries. However, such experiments are strongly limited in sensitivity, preventing studies of low-sensitivity nuclei, minority species, and fast-charging processes.

Lipid nanoparticles (LNPs) are a newly emerging type of drug formulation that encapsulates biological molecules such as nucleic acids and proteins. They have recently emerged as effective vehicles for mRNA vaccines. The performance, stability and delivery properties of these particles crucially depe

Misregulation of the quantity of Cu(II) is connected to diseases. It is then highly desirable to image it by MRI to gain more insight into homeostasis, diseases, and allow early diagnosis. However, conversely to Zn(II), Cu(II) detection is still in its infancy. One challenge is the selectivity of th

Chirality is a fundamental property of symmetry at all scales, from (bio)molecules to (nano)particles and up to macroscopic objects. Besides its fundamental role played in living organisms where it enables biological functions, chirality is of paramount importance in light-matter interaction as well

The project EPAD aims to provide a theoretical framework to investigate positron-electron dynamics in atoms by means of recent experimental spectroscopy methods developed in attoscience. The positron is the anti-particle of an electron, identical to this latter except for carrying a positive charge.

This project aims at the design and synthesis of novel polymers derived from renewable feedstocks with application as commodity or specialty materials (e.g. flexible sustainable packaging), using a synergetic computational and experimental dialogue. For this purpose, artificial intelligence models b

The physical understanding of particle transport within liquid-saturated porous media is a prerequisite in many environmental and industrial fields, such as transport in soil, aquifers, petroleum rocks, building materials and catalysts. Currently the leading field for tracking particle dynamics in m

Cosmic dust plays a crucial role in the physical and chemical evolution of the interstellar medium. It exists an abundant population of nanometer size grains (named nanograins) which have a high surface over volume ratio. These nanograins are expected to be strongly coupled to the gas phase and to c

Proteins are inherently dynamic and adopt multiple conformations, often transiently, to perform their functions. Many current biophysical techniques overlook these elusive conformational states. However, despite their low population, these states play crucial roles in various biological processes. T

Lipids are a heterogeneous class of biomolecules involved in energy storage, signaling, and modulation of membrane protein functions. Lipids are complex metabolites with significant structural and functional diversity, due in particular to the coexistence of multiple isomers. Lipids' molecular struc

With the increasing concentration of CO2 in the atmosphere, there is an urgent need to find new materials for carbon capture. In this context, oxygen-based sorbents are very attractive alternatives to traditional amine-based compounds, and are the object of active research. However, many aspects of

In this project, we propose to study electrochemical reactions under strong vibrational excitation of the molecules along the reaction path. For this purpose, we will design specific electrodes allowing to significantly concentrate the infrared excitation at the surface where the electrochemical rea

The objective of the project is to develop a new concept for the quantification in trace metal speciation analysis, and, in particular, in large-scale analysis of metal-complexes with low molecular mass ligands (metallo-metabolomics) and proteins (metalloproteomics). The concept is based on the

Electron Paramagnetic Resonance (EPR) is a powerful spectroscopic technique introduced in the 1940s that enables the examination of systems containing unpaired electrons. This technique’s broad scope spans semiconductor analysis, structural biology and chemistry, quantum computing, dosimetry, or foo

The DIAPASONS project aims at improving our knowledge of the role of (nano-)grains in the physics and chemistry of the interstellar medium via atomistic modeling using a state-of-the art methodology based on Deep Potential Molecular Dynamics (DPMD). There is indeed a crucial lack of accurate theor

CO2 fluids are crucial in eco-friendly technologies, from geological storage to industrial processes (separation, extraction). Their development necessitates a clear understanding of the structure and thermodynamics of CO2 fluid across various scales, pressures, temperatures, and complex environment

In our cells, gene activity is tightly controlled by reversible chemical modifications called epigenetic marks. These are of various types and modulate gene accessibility without affecting the DNA sequence. The modification of the histone proteins, responsible for DNA compaction in the nucleus, is o

The FIBERSPEC project is part of the current dynamics of laser sources and optical sensors, in particular IR sensors. It focuses on the development of highly selective and sensitive biosensors which represent a growing societal need and have potential applications in medicine and health control, env

The understanding of interaction between matter and light is one of the keys to unlock our understanding of natural phenomena, be it from a fundamental or application-oriented research standpoints, since light-matter interaction is central to many technologies and processes that are central to our s

Complex reaction mechanisms are ubiquitous in chemistry. Many processes in transition-metal catalysis, polymer chemistry, enzyme catalysis and environmental chemistry involve a multitude of competing reaction pathways. Even in regular (organic) synthesis, the potential appearance of a plethora of (u