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Geometric measure theory and applications – GEOMETRYA
We shall address several problems within the framework of geometric measure theory, from both theoretical and numerical viewpoints. Our project is divided into 5 topics : 1) Geometric measure theory in singular metric spaces 2) Plateau problems 3) Around the Mumford-Shah functional 4) Irrigatio
Artificial Intelligence for Health, Physical Models, Transportation and Defense – AHEAD
AI has a major impact in essentially all fields in science and humanities. At Cnam, several laboratories are developing research programs in AI. This proposal gathers actors from computer science and applied mathematics, which perform fundamental research in AI, and institutions using AI technologie
Coupling between hydrodynamics and surfactant transport at interfaces: experimental and numerical challenges. – HydroSurfDyn
The two phenomena involved (hydrodynamic and transport of surfactants) are widely studied in the literature, but their coupling is still often misunderstood. The boundary conditiosn for the flow are not known a priori, but they must be determined from the coupling between the flow and the surfactan
Predictive Maintenance of transportation systems under incomplete and imprecise data – MAPSYD
The original contributions of the MAPSYD project can be broken down according to the themes below: - Dependability : The first innovative element is the integration of the dependability in the process of predictive identification of system failures. - Predictive modeling in the presence of unc
Monge-Ampère and Computational Geometry – MAGA
The (real) Monge-Ampère equation is a fully nonlinear elliptic equation with a strong geometric nature. It can indeed be used, following Minkowski, to recover a convex hypersurface from the knowledge of its Gaussian curvature. This equation also plays a central role in the theory of optimal transpor
Exploring the P-glycoprotein-mediated efflux transport at the blood-brain barrier as a biomarker of drug-resistance in focal epilepsy – EPIFLUX
Epilepsy is one of the most common serious neurological disorders, affecting approximately 65 million people worldwide. Seizures can be controlled by antiepileptic drugs (AEDs) in most cases. However, ~30% of patients have drug-resistant epilepsy (DRE) and experience debilitating refractory seizures
Maritime Globalization, Network Externalities, and Transport Impacts on CitieS – MAGNETICS
The team wishes to demonstrate that the global maritime network went through several phases of rationalization and optimization since the late 19th century, at the expenses of its ties with urban settlements. Theories proposed by regional scientists explain that such an evolution is beneficial to no
New light-driven channels and transporters for optogenetics – NEWOPTOGENETICSTOOLS
Optogenetics is one of the most important technological recent advances in biology. It revolutionized our ability to study the mechanisms of processes in neuronal circuits, promising new approaches to the treatment of different diseases and handicaps. The core tools of optogenetics are light-driven
Innovative concept and tools for smart grid applied to railway transportation – CONIFER
It is expected to have a growth of the rail traffic in the coming years which would face a growing energy consumption connected to: the big socio-economical development expected indicates the increasing fourfold of the travellers’ demand on the horizon of 2030. Also, as far as the goods transportat
Triggering selective apoptosis of multidrug resistant cancer cells overexpressing ABC transporters – Achilles
The aim is to identify compounds targeting multidrug-resistant cancer cells overexpressing ABC transporters for triggering their apoptosis. These compounds, by difference to classical inhibitors of drug-efflux pumps, produce collateral effects by targeting critical components of the pathophysiologic
