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Treatment of proton transport-related congenital disorders of glycosylation by manganese supplementation – TreatProCDG
Glycosylation is a protein and lipid posttranslational modification influencing many biological and physiological processes. Thousands of proteins are ‘glyco-proteins’. As a result, genetic defects in glycosylation pathways lead to mostly severe diseases, called ‘Congenital Disorders of Glycosylatio
What role for energy in synaptic plasticity? Deciphering the impact of glutamate and lactate transporters by lentiviral targeting. – Neuroenergetics
It is increasingly recognized that energy consumption is a key constraint on neural function. To ensure optimal efficiency in synaptic transmission, plasticity and energy supply of local networks, multiple molecules are exchanged between neurons and astrocytes. A major breakthrough in the understand
Cooling devices based on non-equilibrium transport in semiconductor heterostructures – GELATO
GELATO aims at designing disruptive highly efficient thermionic cooling nano-devices. It is motivated by the urgent technological need to control joule heating in nanoelectronics in a context of energy shortage. So far, most of the studies on solid-state cooling are based on the classical thermoelec
One dimensional spin-quantum transport in molecular wires – MQwires
Current industrially exploited technologies for the fabrication of nanoscale devices and further improvements of new kind of consumer electronics are based on the down-scaling of conventional semi-conductor technology. The inclusion of organic materials is so far limited to the optimization of mater
Ecodesign of fruit and vegetable postharvest chain: Optimization of packaging and cold chain – EcoFreshChain
The objective is to design a new biodegradable cellulose packaging and combine it with refrigeration to preserve fruits and vegetables along the post-harvest chain until consumption. Several issues related to the developed packaging are studied: heat/moisture transfers and air flow within the pallet
Optimizing mechanical properties of nickel base superalloys by tailoring microstructure – OPALE
The project aims at improving the mechanical behaviour of polycrystalline Nickel base superalloys, by tailoring the microstructure of as-shaped pieces. Those alloys are used for manufacturing turbojet engine components, due to their excellent mechanical strength at high temperature. Improving the ma
Intense Laser Optical Optimization for Propagation – ILOOP
Traditionally the intense laser beam at the end of the chain , after compression , has a Gaussian amplitude distribution type, or super- gaussian. This is teh eigenmode of the system and theassociated spatial phase is quasi plane if a deformable mirror is implanted or aberrant if it is not the case
Understanding and optimization of local electrografting – COPEL
Organic coatings on surfaces are present everywhere in today’s life, from paints used in car industry to medical devices. Among the different coating techniques, electrografting which is based on the electro-induced polymerization of dissolved electro-active monomers on metallic or semiconducting su
Design of calix[n]arenic detergents for structural and functional studies of ABC transporters – Stabicalix
1-Context and objectives of the project Our main objective is to obtain the first 3D-structure at atomic resolution of a MultiDrug-Resistance (MDR) ATP-Binding Cassette (ABC) transporter, a class of proteins for which biomedical interest is considerable and for which functional and structural data
A prospective analysis of the tensions between higher self-sufficiency and a healthier, more sustainable food system – SOUVNUTRI
How and to what extent the French food production system could ensure healthy and sustainable diets for its population while increasing its capability for self-sufficiency? From a political point of view, there is a growing demand from consumers/citizens for what is considered a better control of
