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A TARGETED METABOMOLIC APPROACH TO DESIGN A PREDICTIVE MODEL FROM THE MONITORING OF THE INFLAMMATORY MEDIATORS KINETICS IN PATIENTS ADMITTED TO INTENSIVE CARE UNIT WITH COVID-19 PNEUMONIA. – COVID-METAFLAM
Beginning in December 2019, a novel coronavirus, designated SARS-CoV-2, has caused an international outbreak of respiratory illness termed Covid-19, requiring for a small proportion of patients, admission to Intensive Care Unit (ICU). However, despite the urgent needs of therapeutic guidelines, litt
Acoustic and Optic bioSensors for label-free CoVId-19 fast diagnosis – AcOstoVie
The world is currently facing a pandemic of a new emerging virus from the coronavirus family named COVID-19. Detection of infected patients is crucial to break the epidemic situation. As a consequence it is essential to diagnose fast and in large number populations to sort rapidly those who are infe
AiR mOnitoring high-riSk area: Air monitoring of coronaviruses (SARS-CoV2) presence in high-risk area – ARISE
The ARISE project will produce an air analyser equipped with detection capabilities for the ubiquitous monitoring of airborne SARS-CoV-2 pathogens to monitor confined environments. COVID-19 is a recently occurring disease caused by the SARS-CoV-2 coronavirus. Its spreading is rapid and hard to cont
An integrative biology approach to study DNA primase: the swiss-knife of Archaea – ARCHAPRIM
The DNA of all organisms is constantly damaged by exogeneous and endogenous agents. A complex interplay between DNA replication, recombination and repair is required to ensure faithful passage of the genetic material from one generation to the next. Our understanding of how these DNA replication, re
An original public service between past and future: Public baths in France and Western Europe – THERMAPOLIS
While the issue of access to water is mainly analysed in southern countries, THERMAPOLIS addresses it in European cities through the example of public baths and community showers. Indeed, while easy access to water and sanitation in Northern countries is one of the indicators of their economic and s
Artificial-Intelligence-based Methods for Nanobody Design – ANDES
ANDES aims at developing and experimentally validating new computational methods for nanobody design, with a large spectrum of applications (therapies, diagnosis…) in order to have efficient technological solutions, ready to react very quickly and to face the emergence of new viruses. Our ambition l
Autoantibodies against type I IFNs in Lebanese patients hospitalized with COVID-19. – AAILC
Since 2003, three coronaviruses, SARS, MERS, and SARS-CoV-2, have led to devastating pandemics. Although vaccines are available, new variants and even new coronaviruses could emerge at any time. Understanding the molecular and cellular basis of human protective immunity against SARS-CoV-2 is critica
Bioinspired scaffolds to fight human coronaviruses – CoroNat2
The COVID-19 pandemic caused by SARS-CoV-2 has highlighted the urgent need to identify antiviral compounds against human coronaviruses (HCoV). The multidisciplinary CoroNat2 project involves 4 complementary teams, each with pre-existing technical expertise in virology, phytochemistry, chemistry and
CK2 inhibitors as chemobiological tools to unravel CK2 role in SARS-COV-2 lifecycle and as potential antivirals with broad-anti-coronavirus activity – CK2COV
In 2020, the global phosphorylation landscape of SARS-CoV-2 infection was revealed, showing that phosphorylation signalling represents a primary host response to viral infection. In this study, casein kinase II (CK2) appeared to be involved in SARS-CoV-2 lifecycle, suggesting that targeting CK2 shou
COVID 19 Rapid diagnosis test (development and clinical validation in 7 weeks) – CORaDiag
COVID-19 is an acute respiratory disease caused by novel coronavirus SARS-CoV-2 also known as 2019-nCoV. On March 11, 2020, the World Health Organization (WHO) characterized COVID-19 as a pandemic. The disease is spreading worldwide. The World Health Organization has declared a global health emergen
