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Immunostimulating molecules with a broad-spectrum antiviral activity: a proof of concept in non-human primate models – STING-2.0
Our therapeutic arsenal to treat virus-infected patients is extremely limited, and there is a critical need for broad-spectrum antiviral molecules that could be used against multiple viruses. Among possible strategies, the idea of molecules stimulating the innate immune response in host cells is of
SARS RNA Synthesis and Processing Activities – SARS-RNA-SPA
Unraveling the SARS-CoV replication mechanisms are essential to the development of new antiviral strategies. We decipher how the enzymatic activities present in the replication transcription complex are interconnected to ensure the replication of the viral genome and their addition of a cap structur
Ecoepidemiology of coronaviruses, from wildlife to the human population, and assessment of the emerging potential – EPICOREM
More than 60% of infectious diseases in humans are caused by pathogens likewise circulating in domestic animals and wildlife. Most of these pathogens are viruses whose genome is an RNA molecule. RNA viruses are characterized by their genetic diversity, a population structure in quasispecies, a high
Identification of novel inhibitors against emerging human coronaviruses SARS-CoV and MERS-CoV from host cellular transcriptionic signatures – CoV-SigN
In 2012, a novel human coronavirus (MERS-CoV) was identified in the Middle East as the causative agent of a severe acute and/or fatal respiratory syndrome. Since its identification, it has been responsible for 211 laboratory-confirmed cases including 88 deaths. Most cases are sporadic but human-to-h
Rabies virus RNA capping machinery as antiviral target – RAB-CAP
Mononegavirales such as Ebola, rabies, VSV and measles virus are non-segmented negative strand RNA viruses causing important public health threats. Although prophylactic or post exposure vaccination is available against a limited set of Mononegavirales, we lack antiviral molecules for the treatment
New diagnostic and therapeutic solutions to cotrol bleeding complications during the use of mechanical circulatory support devices
Le développement d'un "bio-stéthoscope quantitatif" basé sur l'analyse du VWF clivé au point-of-care (POC) est en cours. Le développement d'un test basé sur les nanocorps pour quantifier la dégradation du VWF a été effectué. Deux nanocorps permettant la quantification du VWF ont été sélectionnés. Le
Sustainable intensification of fruit production systems through innovative pest biological control technologies – Pest free fruit
The proposed Project aims to develop and promote novel, cost-effective and system-wide biocontrol technologies that contribute to the sustainable intensification of fruit production, particularly for small-scale growers in Africa. Main objectives include developing transformative pest control based
Inhibition of coronaviruses infections using innovative nanostructures – NanoMERS
The main objectives are 1. Identification of most promising anti-MERS-CoV nanostructures using in vitro tests 2. Determination of the pharmacokinetic of the best nanostructures 3. Pulmonary delivery using nebulization of mice 4. Testing of most promising anti-MERS structures in MERS-CoV infecte
Quantum Dots as Redox Photocatalysts for Organic Synthesis – PhotoRedoQs
In the last decade, the emergence of photoredox catalysis has revolutionized the field of synthetic organic chemistry. Catalyst design has been boosted by development of catalysts for solar energy conversion. Ruthenium and iridium coordination complexes are playing a major role in this development.
AiR mOnitoring high-riSk area: Air monitoring of coronaviruses (SARS-CoV2) presence in high-risk area – ARISE
The ARISE project will produce an air analyser equipped with detection capabilities for the ubiquitous monitoring of airborne SARS-CoV-2 pathogens to monitor confined environments. COVID-19 is a recently occurring disease caused by the SARS-CoV-2 coronavirus. Its spreading is rapid and hard to cont
