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Tackling antimicrobial resistance in hospitals: a holistic eco-evolutionary model of resistance gene dissemination to optimize intervention strategies – ResisTrack
Designing and evaluating effective strategies against antimicrobial resistance (AMR) in hospitals is difficult. We aim at evaluating candidate interventions of antimicrobial stewardship and infection control (AS/IC) in silico. Building upon recent advances in ecology and systems biology, we will construct and calibrate an integrative ecological and evolutionary model of resistance dynamics, implementing the dissemination of ARGs, mobile genetic elements and bacteria under antmicrobial pressure.
DihydrouridinE RNA modification marks: written and erased by the same enzyme – DERASE
Cellular RNAs contain chemical modifications originally thought to be static, and utilized to fine-tune RNA structure and function. Some RNA methylations may be reversed to modulate RNA processing. Surprisingly, little attention is paid to reversible modification of tRNA and rRNA. It is quite plausible that reversible modifications at the tRNA and rRNA levels might also be harnessed by nature via evolution to directly affect translation. A point in case here is dihydrouridine (D).
Wealth Inequalities and the Dynamics of Housing Market.Interpreting real-estate market-based regime of spatial inequalities (WIsDHoM) – WIsDHoM
The project investigates how asset-based welfare policies, residential market volatility, stratified accumulation and vulnerability impinge upon the geography of inequality in property markets. Since the 1990s, housing prices have increased faster than the income of buyers, becoming a driver of social polarization and household vulnerability. We investigate the links between socio-spatial inequality, asset capitalization, instability and vulnerability in residential housing markets.
Algorithms with Small Separations acKnowledged: graphs and linear matroids – ASSK
The main theme of this project is small separation phenomena on graphs and linear matroids, emphasizing the applications on algorithms design. The concept of separation in theoretical computer science is pervasive, in varying forms depending on the context. It is a fundamental concept that paves the way for graph theory, especially structural decomposition theory. Also it serves as a major engine for algorithms design.
Hominin BipedalismS: Exploration of bipedal gaits in Hominins thanks to Specimen-Specific Functional Morphology – HoBiS
Functional Exploration of bipedal gaits in Hominins thanks to Specimen-Specific Functional Morphology
PIGIMMUNITY: a systems biology approach to boost innate immunity in the pig – PIGIMMUNITY
Stimulation of innate immunity has been identified as a promising prophylactic and/or therapeutic strategy to combat infectious diseases. In this regard, flagellin, a specific agonist of the innate immune system, emerges as a possible alternative strategy to increase resistance to both respiratory and intestinal diseases. PIGIMMUNITY proposes a systems biology approach to determine the factors that control flagellin-induced modulation of the immune system
Better understanding the evolution of angular momentum in red giants – BEAMING
Measurements of internal rotation in stars at various evolutionary stages have shown that angular momentum is redistributed much more efficicently than predicted by current models. The BEAMING project explores the hypothesis that internal magnetic fields are causing this additional transport of angular momentum in red giant stars.
Crystalline product assisted by intensified CO2 process – CYPRES
The project evaluates the possibility of controlling the structural and enantiomeric purity of compounds of pharmaceutical interest possibly formulated in cocrystals via the use of compressed CO2. CO2 should allow access to metastable equilibria favourable to co-crystallization, chiral resolution, or both. The development of CO2-assisted processes could thus meet the industrial demand for rapid and efficient selective crystallization.
Design of an improved Calvin-Benson Cycle for efficient CO2 fixation and photoproduction of biofuels and chemicals by microalgae and cyanobacteria – CalvinDesign
Photosynthesis is limited by the capacity to fix carbon. A better understanding of these limitations is a major challenge to improve not only the production of biofuels and photosynthetic bioproducts but also agricultural yields, which have been stagnating for several years.
Development of an ultra-thin monitor for charged particle beams – PEPITES
High-performance, robust and reliable monitors ensure the quality of radiotherapy by proton beam used in cancer treatment. During the irradiation of the patient, the monitors are continuously crossed by the beam and must be as thin as possible so as not to disturb it; they must also have excellent radiation resistance to last over the long term. PEPITES offers an innovative approach in this area.
