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Towards Ligand-Induced Fluorescent Proteins – InducedFluo
The UnaG protein emits intense and bright green light once the bilirubin (BR) ligand is bound to the protein. BR is an indirect marker of various human liver functions UnaG is therefore a promising direct medical tool to track liver disease as well as a probe to detect cardiovascular diseases. The project aims to model this new class to understand its electronic, spectral, and conformational properties as well as to design new ligands or mutants enlarging the possible applications.
The SPIRou Planet Search for Habitable worlds – SPlaSH
Exploitation and coordination of the SPIRou Legacy Survey, a radial velocity survey dedicated to the search (for) and characterization of low mass exoplanets around M dwarfs.
Pristine — A survey of the first Galactic stars – Pristine
The most efficient path to understanding the formation of the Milky Way into a disk galaxy during the first few billion years of the universe is to search for, map, and study the dynamics of primordial stars as these stars are the only remaining witnesses of these very early times.
Vector Boson Scattering as an indirect probe of new physics – VBStime
Run3 periods of LHC exploitation (2015-2018 and 2021-2022), create a synergy between ML and high-energy
Dissecting Type Four Pili in Action – T4PNanoAction
Type IV Pili (T4P) are filamentous cell surface structures present in numerous bacterial pathogens including Neisseria meningitidis and highly involved in virulence. A nanomachinery anchored in the bacterial wall constantly assembles and disassembles T4P. The aim of this proposal is to dissect the different steps leading to a functional T4P nanomachinery by combining innovative in vivo cross-linking mass spectrometry (XL-MS) and cryo-Electron Microscopy (cryo-EM) approaches.
Molecular mechanism of transcription by influenza virus polymerase – FluTranscript
Influenza virus is a perennial threat to worldwide public health due to the morbidity and mortality that it causes, its ease of transmission and its unpredictable evolution. The influenza RNA-dependent RNA polymerase (FluPol) is the key virally encoded molecular machine that performs transcription and replication of the segmented negative-sense RNA genome. A detailed understanding of how FluPol preforms transcription can underpin the development of the next generation of anti-influenza drugs.
Treatment of breast milk by high-pressure processing increases its biological and intestinotropic properties: experimental and clinical studies in preterm newborns. – HHP-humanmilk
High pressure processing protects bioactive compounds of human milk and its intestrophic properties
Short time scale landscape evolution and topographic signature of extreme climatic and tectonic events – TOPO-Extreme
River terraces, knickpoints, alluvial fans and other morphological markers are routinely used to date and quantify landscape response to changes in climate or tectonics over long time-scale (>10.000 yr). However, those markers are rarely used to assess the natural variability of extreme events’ frequency and magnitude because both the formation and the evolution of those markers in response to internal or external solicitations remains poorly studied.
Bio-physicochemistry of tropical clouds at Maïdo (La Réunion Island): processes and impacts on secondary organic aerosols formation – BIO-MAIDO
The tropical environment of the island of La Réunion presents optimal conditions for studying the formation of SOA: (1) many biogenic compounds, SOA precursors, are emitted in large quantities and strong sunlight and high temperature promote their chemical transformations; (2) due to the high occurrence of clouds on slope, this site allows assessing the influence of aqueous processes in the formation of SOA.
Floating treatment wetland for agri-food effluent tertiary treatment – FloWAT
A Nature-Based Solution to mitigate the impacts on the receiving environment
