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Characterization and novel therapeutic options for pigmented villonodular synovitis – PVNS
PVNS is associated with abnormal fibroblastic cells, often involving a specific chromosomal translocation resulting in the overexpression of colony-stimulating factor 1 (CSF1 or M-CSF), recruitment of CSF1 receptor (CSF1R) macrophages and fusion in giant cells. PVNS is the articular form of tenosy
Up-to-date LLM for all – LLM4all
Large Language Models (LLM) of sufficient size exhibit outstanding emergent abilities, such as learning from their input context and decomposing a complex problem into a chain of simpler steps. Both these emergent abilities and the performances that have been published on many tasks tend to prove th
Designing Inhibitors of Phosphopantetheinyl Transferases Of Pathogenic bacteria – DIPTOP
Many mycobacteria are human pathogens: Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis, caused nearly 1.6 million deaths in 2021, and Mycobacterium abscessus (Mab) induces lung infections in patients with cystic fibrosis or weakened defences. Treatments exist but they are lon
Einstein Lensing Rings to Observe the Non-baryonic matter Distribution – ELROND
Weak gravitational lensing is a key probe of the distribution of dark matter in the Universe; it is one of the main focuses of stage-IV galaxy surveys such as Euclid and the Legacy Survey of Space and Time. The standard weak-lensing measure – cosmic shear – consists in observing the apparent alignme
Predictors of Reading and Spelling Acquisition and Disorders in Children with or without Developmental Language Disorder – PRESAD
Learning to read and spell is a central area of children's development and provides the foundation for lifelong learning. In 2021, learning to read was declared major national cause (“Grande cause nationale”) by the French government. This policy decision was taken because national and international
Design of spintronic ferroelectric architectures for ultra-low power memories, post-CMOS logic and neuromorphic computing – SPINFROST
The tremendous increasing of data collection, analysis, storage and processing has raised concerns towards the optimization and rethinking of the edge-computing paradigm. Indeed, moving the data analysis and processing closer to the location where the data is collected and eventually stored, is the
Professionalization and Strengthening of the training at the Faculty of Agronomy of the University of Parakou for sustainable cotton-based production systems – PreFoSyc
The cotton sector is an important source of economic growth and growth-generating activities in Benin, one of Africa's major producers of seed cotton. The increase in production and productivity of its crop and the improvement of access to markets raise a number of challenges: transformation, securi
Photodetectors and modulAtors for free-space optical communications and coherent LIDAR in the Mid InfraRed – PALMIR
The objective of the PALMIR project is to develop and fabricate mid-infrared detectors and modulators operating around 4.8 µm and to implement them in a multifunction transceiver platform to realize a simultaneous telemetry and free-space optical communications demonstration. Several technological b
A Water mass analysis and Exploration of linkS between phytoplankton, bacteria and trace MEtals along the South West INdian GEOTRACES Section – AWESOME-SWINGS
The Southern Ocean is a major sink for anthropogenic carbon, largely controlled by the biological pump, which depends on the availability of macro- and micro-nutrients, including trace metals (Fe, Cu, Zn, Co, Mn, Ni). Microbial processes play a key role in recycling, remineralization, and the modula
Passivation Research Joint Laboratory – OxyMore
Passivation of alloys is a crucial phenomenon for corrosion protection. This phenomenon is based on the formation of a thin oxide film either : - spontaneously, called passive film, - by chemical or electrochemical treatments. The best known of these treatments is the anodisation of aluminium alloys
