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Imperial and provincial responses to environmental and economic challenges on Rome’s frontier in the Egyptian desert (First-Sixth c. AD) – CRISIS
The second half of the third century AD used to be presented as a period of major political crisis within the Roman Empire. Historians have refined this “major crisis of the third century” and stressed the fact that regional situations differed strongly in the Provinces. In Egypt, signs of crisis, including environmental aspects, occur from the beginning of the third century all the way to the sixth century AD.The border region of the Great Oasis (Dakhla and Kharga) serves as an indicator.
Implementing FAIR principles for Theia/OZCAR in situ data information system – FairTOIS
Implementation of FAIR principles in Theia/OZCAR, the national inter-agency information system on land surface research data
Implication of pesticides in the decline of avian flagship species in farmland – PestiStress
Comprendre les effets sublétaux des pesticides et leur implication dans le déclin de l’avifaune en milieu rural
ImportanCe of inflammasOmes in eMerging Environmental Toxin-driven patHologies – COMETH-
people with more than 2000 cases detected since 2021. In this context, it is of major importance to determine
Improving EPilepsy surgery management and progNOsis using Virtual brain technology
stabilisé pour la pratique clinique. Toutefois, en 2021 il y a eu un remaniement scientifique du projet [...] prolongation d’un an a été adressée à l’ANR en Novembre 2021. Au cours de 2022, l’ANR a accordé son accord pour
In silico models of drug transport to enhance personalized medicine – IMOTEP
Decoding Transporter Mechanisms for Better Treatments
In situ delivery of Interleukin-7 to adjuvant mucosal vaccines – VacMucIL7
We demonstrated that Interleukine-7 (IL-7) is produced in infected mucosae and is able to trigger local expression of chemokines when administered either locally or systemically, leading to massive immune cell homing into targeted mucosae. We hypothesize that locally delivered IL-7 may act as an efficient adjuvant to trigger mucosal immune responses to vaccines.
In situ microviscosity measurements in complex systems by using molecular rotors. – MicroVISCOTOR
The microrheology of complex systems faces significant challenges: 1) in situ measurements within confined systems; 2) on line measurements in dynamic microsystems, and 3) viscosity mapping at the nanoscale. <br />MICROVISCOTOR proposes o develop a cost-effective microfluidics device capable to measure and map on-line and in real-time spatially- and time-resolved microviscosities of complex fluids by using molecular rotors.
In vivo G-Quadruplexes Topologies and Identification of Proteins Partners – G4-TopIPro
We propose the use of G-quadruplex systems constrained in a single topology to identify and characterize the proteins which interact with a well-defined G-quadruplex topology. We also propose to use this concept to generate specific antibodies of a given G-quadruplex topology in order to determine what is the nature of the G-quadruplex topology in vivo.
In vivo gynogenesis in maize: novel insights into plant double fertilization – NOT-LIKE-DAD
A deviation from the classical double fertilization process of higher plants induces in peculiar maize lines haploid embryos containing only the maternal genome. This project aims to use this unique maize line as tool to better understand plant sexual reproduction.
