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New selective Inhibitors for deciphering Lipid metabolism and virulence in M. tb – LipInTB
Tuberculosis (TB) caused by the pathogenic bacterium Mycobacterium tuberculosis (M.tb), is the deadliest infectious disease worldwide. Treating TB takes a minimum of 6-9 months. The emergence of drug resistant strains amplifies the incidences of TB, mainly resulting in failure of treatment and death. There is thus an urgent need for novel therapeutic targets and approaches.
New diagnostic and therapeutic solutions to cotrol bleeding complications during the use of mechanical circulatory support devices
coronavirus a ralenti les inclusions en 2020 et 2021, mais nous avons collecté du matériel biologique
New approaches to bridge the gap between genome-scale metabolic networks and untargeted metabolomics – MetClassNet
New approaches to bridge the gap between genome-scale metabolic networks and untargeted metabolomics
New POLlutant EMIssions from modern Euro 6 CarS: atmospheric transformations and implications for urban air quality and health – POLEMICS
The demand for urban mobility is steadily increasing and the growing number of vehicles in cities poses major environmental and health issues. POLEMICS addresses urgent questions on new Euro6 car emissions. The consortium composed by analytical mass spectrometry experts, toxicologists and air quality modellers will investigate the nature, the fate and the impacts on air quality and health (toxicity and genotoxicity) of Euro 6 emissions combining in laboratory and real world measurements.
New FIber-Optic Temperature Sensors For Measuring Subsurface FLOWs – FIFLOW
electrically heated Fiber-Optic cable (Simon et al., 2021). To fully explore the potential of this innovative
New Atomic Layer Deposition Route for Boron Nitride Thin Films – ALaDiN
A new ALD approach for BN is developed based on the chemical route of polymer-derived ceramics. It consists of 2 steps: (1) ALD deposition of a pre-polymer film with a controlled thickness, (2) post-treatment to convert the ALD deposit into BN. This process allows the fabrication of Van der Waals BN/C heterostructures as well as highly crystallized BN nanostructures. The latter have proven to be very interesting for water purification.
New Antibiotics Tackling mUlti-Resistance by acting on Alternative bacteriaL tARgets in Synergy with mEmbrane-disruptiNg AntimicrobiaL peptides. – NATURAL-ARSENAL
Understanding the mode of action of new natural antibiotics in synergy with membrane-destabilizing antimicrobial peptides
Natural Breaking WavEs and Sediment Transport during beach recovery – WEST
WEST project focuses on Wave Boundary Layer and sediment transport at the land-sea interface, specifically on sandy beaches. It relies on the combination of observations and modeling approaches to understand the variability of the coastal environment and aims to fill the gap between theory and in situ measurements of nearshore dynamics.
National instrumentation in cryo electron microscopy
2022 by videoconference. Started in 2021, we have finalized the purchase procedure for the
Naphthalene C-H Bond Functionalization: New Methodologies and Total Synthesis Application – NaFMeTS
Naphthalene is a key structural core in chemistry as shown by its presence in many bio-active compounds as well as in organic materials. However, reported synthesis are often steppy. The goal of this project is to develop new C-H activation reactions to introduce regioselectively different functionnal groups on naphthalene derivatives and to apply theses methods to natural products synthesis.
