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Engineering RNA life cycle to optimize economy of microbial energy: application to the bioconversion of biomass-derived carbon sources – RIB-ECO
Improving the performance of microbial platforms to transform biomass into bioproducts is crucial for the development of sustainable and economically relevant biotechnological processes. Metabolic engineering to optimize expression of native or heterologous pathways often leads to significant energy
Role of Tbx3 in directing the functional identity of POMC neurons in obesity – neuroIDobese
While executing the experiments mentioned in Aim 1, we encountered a few technical issues that we have been able to overcome by successfully introducing backup strategies. In the original plan, we proposed the use of single-cell mRNA sequencing from ARC micro punches and/or FACS sorting to achieve t
Analysis of SNARE-mediated regulation of plasma cell biology – PC-SEC
Antibodies (Ab) are essential for efficient and long-term protection against infection. They are produced by plasma cells (PCs) corresponding to the last stage of B cell differentiation and play an essential part in host protection and tissue homeostasis directly by neutralizing pathogens but also b
Temporally Heterodyned Theta Tomographic Microscopy – THTTM
Coupling heterodyne holography with true 3D imaging might allow to: - Focus on selected features. Selective 3D reconstruction of the studied bio-sample will be possible. - Functionalize conventional TDM by adding new modalities like 3D laser Doppler imaging. To the best of our knowledge these ima
Rainfall Wind Turbine or Turbulence – RW-Turb
Few studies showed that the effects of rainfall (rain rate and drop size distribution –DSD-) on wind turbine efficiency are significant, but have surprisingly received little attention. The main goal of WR-Turb is to overcome the current lack of knowledge on this topic through a genuine collaboratio
Data and Prior, Machine Learning and Control – DeLiCio
We combine machine learning (ML) and control theory (CT) and address problems in control from two perspectives: - What can be modelled (CT) and what needs to be learned (CT)? - Can we provide, estimate or guarantee stability (CT)? - Can we estimate the complexity of the learning task and or the a
Transformations to Groundwater Sustainability : joint learnings from human-groundwater interactions – T2GS
The project set out to comparatively study promising grass-roots initiatives of people organizing around groundwater in places where pressures on water are acute (India, Algeria, Morocco, USA, Chile, Peru, Tanzania). As these often defy conventional wisdom, the project's hypothesis is that these ini
Structural dynamics of a dimeric GPCR at the single molecule level – DynaMuR2
The objectives of this program are to be able to record the different conformational changes of the mGlu2 receptor. This receptor consists of two subunits, and each of them is made of «main structured domains: the binding domain, the cysteine-rich linker, and the membrane domain. We want to record t
Microscopie electronique en transmission sur le plateau Palaiseau Orsay Saclay
TEMPOS est une plateforme en microscopie électronique en transmission sur le plateau de Saclay rassemblant des équipes de l’Université Paris-Saclay et du CNRS, de l’Ecole polytechnique et du CEA. L’originalité de ce projet tient dans le développement d’une instrumentation innovante en microscopie en
Paris Sciences & Lettres Avec et Pour la Société – ANR22 – PSLAPS-ANR22
PSL University is a signatory to the charter of research and participatory sciences of March 20, 2017. PSL University obtained the Sciences Avec et Pour la Société label issued by the MESRI in 2021. PSL University won the calls, opened in December 2021, November 2022 and April 2024, which concern
