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Role of cAMP signalosomes in cardiomyocyte senescence and age-associated heart failure – SIGNALAGE
Recently, senescent cells accumulation has emerged as a main driver of age-associated diseases. In the lab, we have recently shown that aged cardiomyocytes acquire a senescent-like phenotype characterized by persistent telomere DNA damage and activation of classical markers of senescence. In additio
Role of adipose mitochondrial CB1 signaling in the regulation of energy balance – MitoCB1-Fat
Our research project aims at investigating the roles of mtCB1R in adipose tissue. We will use in vitro and in vivo models, and we will use normal and diet-induced obesity conditions. Our goal is to identify adipocyte mtCB1 as a potential therapeutic target in the treatment of pathological metabolic
Role of Type IV pilus retraction in bacterial pathogenesis – RETRACTOPATH
Neisseria meningitidis (meningococcus) is a bacterium responsible for septicaemia and meningitis in humans. It interacts with vascular cells via its Tfp and promotes the formation of purpuric lesions often evolving towards a fatal outcome. The overall objective of this proposal is to decipher the
Role of Tbx3 in directing the functional identity of POMC neurons in obesity – neuroIDobese
While executing the experiments mentioned in Aim 1, we encountered a few technical issues that we have been able to overcome by successfully introducing backup strategies. In the original plan, we proposed the use of single-cell mRNA sequencing from ARC micro punches and/or FACS sorting to achieve t
Role of Piezo1/KCNN4 interaction in red blood cell physiopathology – ROPKIP
In this project, we want to analyze the coupling between PIEZO1 and KCNN4, identify partners likely to regulate their functioning in order to propose avenues of therapeutic investigation to prevent hemolytic anemias associated with mutations in PIEZO1 or KCNN4. We characterized new mutations in the
Role of Piezo1 in pulmonary arterial hypertension – HTAP
Our specific aims are: 1) to establish a functional link between Piezo1 and the mechanosensitive ion channels in PA SMCs; 2) to identify the role of Piezo1 in acute hypoxic pulmonary vasoconstriction and PA remodeling associated with chronic hypoxia; 3) to explore the signaling pathways downstream o
Role of Corticoids in Ocular Rosacea – ROCOR
Due to the limited understanding of disease mechanisms and the lack of specific diagnostic tests, OR is underdiagnosed. Yet, it is estimated that 10 to 50% of patients with skin rosacea (representing 10% of the general adult population) have ocular involvement. The current therapeutic options offer
Role Of C-di-GMP in the Kinetics of legionella Effector Translocation – ROCKET
Secretion system (SS)-mediated delivery of effector proteins into host cells plays a key role in bacterial virulence. Despite recent progress in the structure-function studies of various SS (e.g. T3SS, T4SS, T6SS, etc.), the signals that activate effector transfer have largely remained a closed book
Robot collaboratif – CoBot
To date, the necessary safety conditions for collaboration between machine and man have not been met. Humans have a flexible architecture and their behaviour has been largely optimised in the course of evolution. Despite the technological progress of recent years, no robot can yet collaborate with h
Risks and Uncertainties under Climate Change
The RISCCI project began in September 2018, and its core development has been the creation of an ensemble platform to explore parametric uncertainty in the MeteoFrance climate model, CNRM CM6. The simulations informing the scientific deliverables have now been completed, one paper is in final revis
