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Super-resolution imaging of bacterial division – DIVinHD
Using complementary cellular and structural biology approaches, the DIVinHD project has provided information that allowed to better understand how, at the molecular scale, the assembly and activity of the cell wall synthesis machineries contribute to cell morphogenesis and division in the human pathogen Streptococcus pneumoniae. These studies have thus provided new and necessary knowledge for the discovery of new antibiotics.
Subsea Water Isotope Sensors: A novel tool for continuous and in-situ analysis – SWIS
The isotopic composition of seawater represents an important fingerprint of water masses, containing information about conditions during their formation and evolution. Following at high resolution its spatial and temporal variability in the ocean would allow to discriminate between different water sources. This project proposes to design and construct a new instrument relying on our recent patent able to provide water isotope mapping at very fine spatial and temporal resolution in the ocean.
Sublingual Vaccination by polysaccharide-based patch – BuccaVac
Mucosal administration, and in particular sublingual administration, of vaccines allows the induction of both systemic and mucosal immunity. However, liquid administration leads to a dilution of the vaccine in the saliva. BuccaVac proposes the development of a sublingual patch for the induction of a strong immunity against flu virus by induction of a local response in the upper and lower respiratory tract, providing a strong protection directly at the portal of entry of the virus.
Study on management and learnings of the fight against infection and contamination by the Covid-19 in squats – EGALITES-Covid
Study of management and learning in the control of infection and transmission of the Covid-19 in squats.
Study of the relationship between spectral and metabolic abnormalities and virological characteristics of CoV-2-SARS in COVID-19 patients with neurological disorders – SPECTRO-VIRO-COVID
("COVID-19 long", WHO recommendations in February 2021) in COVID-19 patients. Within the framework of a
Study in Titanium Alloys of Multiaxial Processing – STAMP
High temperature deformation effects on the globularization of Ti64 alloy: experimental et numerical study.
Structure and molecular function of the pseudopilus in type 2 protein secretion pathway – SYNERGY_T2SS
Synergy_T2SS aims to decipher the structure and function or the pseudopilus - the dynamic motor of type II secretion system, and that in three model bacteria.The current models of the secretion mechanism - «piston« and «archimedes' screw« predict different pseudopilus dynamics and interactions with the secreted substrates. We aim to test these prediction using integrative approaches, and to propose a unified and experimentally validated model of type II secretion mechanism.
Structure and function of endogenous TFIID-containing complexes – PICen
TATA-box Binding protein (TBP) is delivered to gene promoters by either TFIID or SAGA complex. These complexes not only nucleate PIC formation, but have been suggested to function also as a transcriptional co-activators by interacting with transcription activators. Importantly, the structure of native PICs is not known, leaving open the possibility that the composition and architecture of in vivo assembled PICs may differ from that reconstituted in vitro.
Structural dynamics of a dimeric GPCR at the single molecule level – DynaMuR2
Our project aims to understand the conformational dynamics of a receptor that is part of the major drug targets.
Structural and functional studies of import and intermembrane space transfer of mitochondrial membrane proteins – MitoMemProtImp
Mitochondria perform numerous biological functions. they produce all cellular ATP (i.e. energy) and perform key metabolic reactions. 99% of their proteins are produced outside mitochondria and have to be imported. Here, we study key steps of the import of membrane proteins into mitochondria, namely how chaperones and receptors collaborate to achieve efficient targeted import. We combine structural biology and in-vivo techniques to go from the atomic level to the cellular relevance.
