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Silicon-based polymers by catalysed dehydropolymerisations – POLCADE
ALKALINE-EARTH METAL COMPLEXES: SYNTHESIS AND IMPLEMENTATION FOR THE PRODUCTION OF NEW SILICONE MATERIALS.
ABSOLUte asymmetric synthesis by means of CATalysts supported on extremely chirally-amplified supramolecular scaffolds – AbsoluCat
A general approach towards absolute asymmetric syntheses achieved by rational design. All industrial processes rely on chiral precursors to produce new chiral compounds and this paradigm is a severe limitation of asymmetric synthesis. Absolute asymmetric synthesis, i.e. the preparation of enantiopure compounds without the help of any chiral species, is still very limited. A general approach towards absolute asymmetric syntheses would thus constitute an important breakthrough.
Roles of cell adhesion and mechanics in cell and tissue polarization – POLCAM
Forward-backward polarization of single cells has been well described, but little is known about the coordinated polarization of cells within epithelial monolayers. Single cell polarization may emerge from a mechanosensitive transition of the actomyosin cytoskeleton. However, it was not clear how and to what extent this symmetry breaking is propagated in a monolayer of cells and the role played by cell-cell junctions.
Impact of Microhomology Mediated End-Joining DNA repair pathway in vivo – i-MMEJ
Double strand breaks (DSB) are a severe threat to genome integrity in living organisms. In the wild environment animal cells are exposed to external DNA damaging such as chemicals or ionizing radiation. In this project, we studied the importance of MMEJ/NHEJ in living animal context by creating Clytia and zebrafish mutants for genes involved in MMEJ or NHEJ.
Bimetallic complexes of photoswitchable phosphines and uses in catalysis – Switch-Phos
The main objective of this project is to develop the synthesis of new photo-switchable phosphorus complexes for catalytic uses.
Activation Mechanism of Bora-Plk1 Regulating Entry into mitosis – AMBRE
Decoding the molecular mechanism leading to mitotic entry
Institut François Rabelais pour la recherche multidisciplinaire sur le cancer
Erika Cosset (accueillie comme équipe au CRCL en 2021) (v) le développement de la start-up Ervaccine (incubée
Epidemiology of sleep complaints and cardiovascular disease in the community – EPICARSLEEP
EPICARSLEEP is a 4-year project in the primary prevention setting aiming to explore simultaneously four inter-related disease pathways (vulnerabilities) that could explain the increased risk of cardiovascular disease (CVD) in individuals with sleep complaints. The role of (1) cardiovascular health, (2) psychosocial risk factors, (3) arterial stiffness and baroreflex sensitivity and (4) circulating microRNAs, inflammatory and non-inflammatory blood biomarkers will be examined.
Family and inequality – FAMINEQ
Over the past 50 years, industrialized countries have experienced profound economic and demographic changes. These changes concern the distribution of income between individuals and the family structure in which these individuals live (lower nuptiality and birth rates, delays in cohabitation, increase in the number of divorces and single parenthood).
Linguistic and Intercultural Mediations in a context of International Migrations – LIMINAL
What do the social spaces of migration do to languages? In what ways do languages challenge migration policies? How can we qualify the languages of migration, the «migralects«? These questions have mobilised the researchers of the LIMINAL programme from 2017 to 2021. On the Franco-Italian and Franco-British borders, in the camps and reception and accommodation centers, the team has developed an innovative methodology to account for a new pragmatics of the languages in migration context.
