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Silicon-based polymers by catalysed dehydropolymerisations – POLCADE
The chemistry of the large alkaline-earth metals (Ae, where Ae = Ca, Sr, Ba) is burgeoning. Many synthetic challenges persist to this day, although Ae complexes act as excellent catalysts for a plethora of organic reactions. In another field, silicones exhibit good fire-resistant properties owing to
ABSOLUte asymmetric synthesis by means of CATalysts supported on extremely chirally-amplified supramolecular scaffolds – AbsoluCat
The challenge of achieving absolute asymmetric catalysis in a rational and predictable manner was achieved by dissociating the catalytic and symmetry breaking / chirality amplification phenomena required for the emergence of single chirality. More precisely, asymmetric metal catalysts have been supp
Roles of cell adhesion and mechanics in cell and tissue polarization – POLCAM
In this project we thus focused on the influence of the interplay between adhesion and the active cytoskeleton on the acquisition of polarization during collective cell migration. This has been developed and challenged both experimentally and theoretically. In line with current understanding of acti
Impact of Microhomology Mediated End-Joining DNA repair pathway in vivo – i-MMEJ
Double strand breaks (DSB) are a severe threat to genome integrity in living organisms. In the wild environment animal cells are exposed to external DNA damaging such as chemicals or ionizing radiation. Multiple conserved pathways exist for the DSB repair, namely homologous recombination, non-homolo
Bimetallic complexes of photoswitchable phosphines and uses in catalysis – Switch-Phos
Currently, work in the field of switchable ligands and catalysts pursues the major objective of controlling complex multicatalytic sequences by an external stimulus, such as light. The originality of our project compared to the previous work of the literature, consists in targeting bimetallic comple
Activation Mechanism of Bora-Plk1 Regulating Entry into mitosis – AMBRE
Cell division (Mitosis) is a fundamental process required for the generation of multicellular organisms, for tissue renewal and homeostasis. Mitosis drives the distribution of an identical genetic material into two daughter cells. Commitment to mitosis must be tightly coordinated with DNA replicatio
Institut François Rabelais pour la recherche multidisciplinaire sur le cancer
L'objectif principal de PLAsCAN est la mise en œuvre d’approches multidisciplinaires dans le domaine de la plasticité des cellules cancéreuses, en s'appuyant sur la force de la biologie du cancer déjà sur site au Centre de Recherche en Cancérologie de Lyon (CRCL) / Centre Léon Bérard (CLB) et en ras
Epidemiology of sleep complaints and cardiovascular disease in the community – EPICARSLEEP
This project will first permit to conduct a head to head comparison of the determinants of the most frequent sleep complaints in order to identify common and sleep complaints specific determinants. This may help to define global and more specific sleep complaint prevention strategies. Second, by ra
Family and inequality – FAMINEQ
The interaction between these economic and demographic trends has remained largely unexplored, while families are a key place in the production and reproduction of inequalities. For example, endogamous marriages could reinforce inequality between individuals. Allocation decisions within households c
Linguistic and Intercultural Mediations in a context of International Migrations – LIMINAL
Based on the major hypothesis that there is a language specific to the recent migratory experience, the initial issues of the LIMINAL project concern the interactions and mediations between migrants and institutional, associative and informal actors in situations of migratory and humanitarian crisis
