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Temporally Heterodyned Theta Tomographic Microscopy – THTTM
THTTM Project aims at characterizing moving samples using Tomographic Diffraction Microscopy (TDM). These aspects will be studied through two main axes:<br /><br />- discrimination of static/dynamic areas of a sample using laser Doppler 3D imaging<br />- Moving object characterization using TDM
Temporal diffusion spectroscopy in nonalcoholic steatohepatitis – STEDI-NASH
Liver disease caused by metabolic dysfunction is an important and growing societal health concern in the context of the rise of obesity and diabetes. Still, noninvasive methods able to accurately diagnose liver disease hallmarks such as ballooning or inflammation, remain elusive. Stedi-NASH ambitions to develop advanced MRI methods based on diffusion and elastography and their accurate in silico modeling to improve the diagnostic capabilities available to doctors.
Telluride glasses as materials for far-infrared applications : a theoretical and spectroscopic investigation – IRTeGlass
Structure of telluride special glasses, transparent in the far infrared domain
Technology diffusion, techies, and firms' responses to shocks – ARFT22
on our previous work, Harrigan, Reshef & Toubal (2021) that is now in the process of revision at the Review
Tax reforms and tax revolts in democracies – TAXREV
Questions linked to the design and implementation of redistributive tax policies have occupied a growing position on the public agenda over recent years. Moreover, the fiscal pressures brought upon by the current coronavirus crisis will ensure that these issues maintain considerable political significance for years to come.
Targeting Glutamine Metabolism to prevent Diabetic Cardiovascular Complications – GlutaDiab
Diabetes and related CV disease are associated to exacerbated inflammation, and an activation into a pro-inflammatory status of myeloid cells. Glutamine (Glut) is a critical fuel for the TCA cycle, a key regulatory checkpoint in macrophage polarization. The reported decreased [Glut] in T2D could reflect aberrant glutaminolysis of blood monocytes. The generated metabolites may trigger molecular mechanisms of pro-inflammatory polarization of monocytes in diabetes associated CV complications.
Targeting D-alanylation of teichoic acids to fight clinically-problematic Gram-positive pathogens – Dalatar
Targeting the D-alanylation of teichoic acids to fight Gram-positive pathogens of clinical interest
Targeting Cancer-Associated Fibroblasts to tackle metastases and resistance to treatment in Triple Negative Breast Cancer
Défini comme une priorité par le "Plan Cancer 2021-2030", le cancer du sein triple négatif est souvent
Target Ion Source for Short-Lived Ion Production – TULIP
The study of exotic nuclei is one of the main avenues of research with a high potential for discoveries worldwide. The TULIP project aims to enhance near-term nuclear physics research possibilities by creating unique radioactive ion beams (RIB) for ambitious subatomic experiments at the national flagship facility SPIRAL based at the Grand Accélérateur National d’Ions Lourds (GANIL) in Caen.
Tackling antimicrobial resistance in hospitals: a holistic eco-evolutionary model of resistance gene dissemination to optimize intervention strategies – ResisTrack
Designing and evaluating effective strategies against antimicrobial resistance (AMR) in hospitals is difficult. We aim at evaluating candidate interventions of antimicrobial stewardship and infection control (AS/IC) in silico. Building upon recent advances in ecology and systems biology, we will construct and calibrate an integrative ecological and evolutionary model of resistance dynamics, implementing the dissemination of ARGs, mobile genetic elements and bacteria under antmicrobial pressure.
