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Temporally Heterodyned Theta Tomographic Microscopy – THTTM
Coupling heterodyne holography with true 3D imaging might allow to: - Focus on selected features. Selective 3D reconstruction of the studied bio-sample will be possible. - Functionalize conventional TDM by adding new modalities like 3D laser Doppler imaging. To the best of our knowledge these ima
Temporal diffusion spectroscopy in nonalcoholic steatohepatitis – STEDI-NASH
While MRI proton density fat fraction is a reliable tool for steatosis, and elastography techniques such as MR or ultrasound elastography are increasingly accepted for diagnosing fibrosis, hepatocyte ballooning and hepatic inflammation remain difficult to diagnose despite being essential components
Telluride glasses as materials for far-infrared applications : a theoretical and spectroscopic investigation – IRTeGlass
Like most of vitreous materials, the intimate structure of tellurium-based glasses is largely unknown. Therefore, the understanding and optimization of mechanical, optical, and electrical properties of these materials are essentially relying on an empirical set of experimental data and approaches.
Technology diffusion, techies, and firms' responses to shocks – ARFT22
In just a few months’ time, the COVID-19 crisis has brought about years worth of change in the way corporations do business. Many firms have accelerated the digitalization of their customer and supply-chain interactions and their internal operations, and have exhibited a surge in investment in these
Tax reforms and tax revolts in democracies – TAXREV
The design of redistributive tax policies is an evergreen in the public discourse. Research on these questions has led to a well-developed “theory of optimal taxation” with seminal contributions by Mirrlees (1971), Piketty (1997), Diamond (1998) and Saez (2001; 2002). These contributions have in com
Targeting Glutamine Metabolism to prevent Diabetic Cardiovascular Complications – GlutaDiab
We hypothesize that targeting glutamine-dependent pathways in monocytes/macrophages may limit the inflammatory phenotype and CV events in diabetes. We will test this hypothesis using the combination of unique human studies, mouse models and genome-wide molecular and epigenomic analyses to dissect t
Targeting D-alanylation of teichoic acids to fight clinically-problematic Gram-positive pathogens – Dalatar
According to the World Health Organization, «antibiotic resistance is one of the most serious threats to global health, food security and development.« The last decades have been marked by the emergence of multidrug resistant bacteria to such an extent that antibiotics which until now were commonly
Targeting Cancer-Associated Fibroblasts to tackle metastases and resistance to treatment in Triple Negative Breast Cancer
Défini comme une priorité par le "Plan Cancer 2021-2030", le cancer du sein triple négatif est souvent diagnostiqué chez des femmes jeunes, avec un risque plus élevé de récidive métastatique précoce et une survie globale réduite. Les défis les plus importants dans ce type de cancer comprennent i) un
Target Ion Source for Short-Lived Ion Production – TULIP
Speed and efficiency are of the essence and must be tweaked to first produce short-lived (tens of milliseconds) alkali RIB before moving to the ultimate goal of metallic RIB in the region of 100Sn. These target-ion sources are designed to operate in extreme environments, and rely on materials able
Tackling antimicrobial resistance in hospitals: a holistic eco-evolutionary model of resistance gene dissemination to optimize intervention strategies – ResisTrack
The main goal of the ResisTrack project is to investigate an array of candidate antibiotic stewardship and infection control (AS/IC) interventions to identify optimal strategies and to understand how antimicrobial resistance genes (ARGs) spread in hospitals. Using in silico simulation of global
