Implementation of a fast and reliable assay for the high-throughput screening of antiviral molecules active against SARS-CoV-2 – Alpha-COV

This year, the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has led to an unprecedented pandemic termed Covid-19 (Coronavirus disease 2019). Even as human trials of candidate vaccines are already ongoing, there is still a doubt that people can develop protective immunity

Ecoepidemiology of coronaviruses, from wildlife to the human population, and assessment of the emerging potential – EPICOREM

More than 60% of infectious diseases in humans are caused by pathogens likewise circulating in domestic animals and wildlife. Most of these pathogens are viruses whose genome is an RNA molecule. RNA viruses are characterized by their genetic diversity, a population structure in quasispecies, a high

Social distancing and pro-sociality in times of acute sanitary crisis – DISTANCING

This project belongs to the priority “Ethics -Human and Social Sciences” and the topic “Representations, perceptions, attitudes, behavior relative to the epidemic”. Context. To stop the current coronavirus pandemic, the governments of most developed countries are implementing drastic measures to

Fe-S clusters as essential cofactor of Coronavirus replication – CoV-FeS

Replicating and maintaining genome integrity is an upmost task for all organisms. To replicate their exceptionally large genome, Coronaviruses (CoVs) employ a unique and sophisticated RNA-synthesis and correction machinery, composed of, at least, the RNA-dependent RNA polymerase (RdRp, nsp12), the h

Coronavirus membrane pores – MemPoco

Coronaviral infection involves remodelling of the host endoplasmic reticulum (ER) to form double membrane vesicles (DMVs); compartments that house the viral replication complexes and RNA. A recent study identified a transmembrane pore that crosses both membranes of the DMV, providing a point of exch

CK2 inhibitors as chemobiological tools to unravel CK2 role in SARS-COV-2 lifecycle and as potential antivirals with broad-anti-coronavirus activity – CK2COV

In 2020, the global phosphorylation landscape of SARS-CoV-2 infection was revealed, showing that phosphorylation signalling represents a primary host response to viral infection. In this study, casein kinase II (CK2) appeared to be involved in SARS-CoV-2 lifecycle, suggesting that targeting CK2 shou

Multi-scale Eco-evolution of Coronaviruses: from surveillance toward emergence prediction – MUSECoV

Coronavirus Diagnostic combined with seasonal Flu Sensing – CorDial-FLU

Worldwide, infections and death from SARS-CoV-2 continue despite lockdown and the use of masks. What started as a temporary sanitary issue, has morphed into a more permanent and long-lasting pan epidemic outbreak. One efficient manner to limit COVID-19 spreading and an adequate means of better manag

Rights of Marginalized during the Coronavirus Crisis: Hospitality and Commitment – DECHE

The lockdown instituted by the government in March 2020 has affected the role of social actors involved with exiled people. Many associations have been alerted to the situations experienced by individuals in precarious situations. As researchers involved in the associative field in Rennes, we wonde

AiR mOnitoring high-riSk area: Air monitoring of coronaviruses (SARS-CoV2) presence in high-risk area – ARISE

The ARISE project will produce an air analyser equipped with detection capabilities for the ubiquitous monitoring of airborne SARS-CoV-2 pathogens to monitor confined environments. COVID-19 is a recently occurring disease caused by the SARS-CoV-2 coronavirus. Its spreading is rapid and hard to cont