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An integrative biology approach to study DNA primase: the swiss-knife of Archaea – ARCHAPRIM
The DNA of all organisms is constantly damaged by exogeneous and endogenous agents. A complex interplay between DNA replication, recombination and repair is required to ensure faithful passage of the genetic material from one generation to the next. Our understanding of how these DNA replication, re
Viral dynamics at the individual and population levels: impact for antiviral treatment optimization – TheraCoV
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which originat-ed in Wuhan, China, has become pandemic and a major concern all over the world. By March 22, 2020, this virus has a?ected more than 320,000 people worldwide and caused more than 14,000 deaths. Despite the un
Role of SARS-CoV-2-infected pulmonary cells and antibody response in COVID-19 outcomes: From pathophysiology to testing candidate drugs in mucosal cell models – MUCOLUNG
Background: The emerging SARS (Severe Acute Respiratory Syndrome)-CoV (Corona virus)-2 is a novel airborne coronavirus threatening public health that is currently spreading worldwide causing the severe respiratory syndrome known as COVID-19 1, for which no treatment is yet available. One of the rel
A TARGETED METABOMOLIC APPROACH TO DESIGN A PREDICTIVE MODEL FROM THE MONITORING OF THE INFLAMMATORY MEDIATORS KINETICS IN PATIENTS ADMITTED TO INTENSIVE CARE UNIT WITH COVID-19 PNEUMONIA. – COVID-METAFLAM
Beginning in December 2019, a novel coronavirus, designated SARS-CoV-2, has caused an international outbreak of respiratory illness termed Covid-19, requiring for a small proportion of patients, admission to Intensive Care Unit (ICU). However, despite the urgent needs of therapeutic guidelines, litt
Réunion Island, Lockdown, Social Inequalities in Health – Ré-Conf-ISS
On November 17th 2019, a novel coronavirus (SARS-CoV-2) became epidemic in Wuhan, Hubei province, China. By, March 11th 2020, the SARS-CoV-2 became pandemic according to the World Health Organization (WHO). Reunion Island, a French overseas department in the South-West Indian Ocean with a long story
Development of RNA aptamers targeting the NADPH oxidase DUOX1 as a therapeutic approach to treat lung fibrosis – APFIBROX
Chronic respiratory diseases, including lung fibrosis are a major and increasing burden in terms of morbidity and mortality. Lung fibrosis is characterized by excessive matrix deposition leading to destruction of lung architecture and ultimately fatal impairment of lung function. Idiopathic pulmonar
Rabies virus RNA capping machinery as antiviral target – RAB-CAP
Mononegavirales such as Ebola, rabies, VSV and measles virus are non-segmented negative strand RNA viruses causing important public health threats. Although prophylactic or post exposure vaccination is available against a limited set of Mononegavirales, we lack antiviral molecules for the treatment
Multi-omic analysis of anti-viral immunity: From the identification of relevant biological pathways to the discovery of inborn errors of immunity – GENVIR
Viral infections remain a major threat for humankind with a number of alarming signs including 1) the limited effect or the absence of vaccines and/or efficient anti-viral drugs against a large number of viral infections, and 2) the recurrent emergence of new viral infections as attested by the rece
SARS-CoV-2 transmission in Food Processing Plants - Emphasis on meat processing plants – SACADA
The main goal of this project is to gain insights on the circulation of SARS-CoV-2 in meat processing plants in France in order to provide preventive or risk mitigation measures for workers and consumers. We are planning to gather/collect the data necessary to understand the circulation of the virus
Collaborative Economy Platform Agents’ Status in the light of SOcial Citizenship – CEPASSOC
The project started from observing the rise of collaborative economy and digital platforms. They are new intermediaries between consumers and providers. These providers or agents have diverse statuses (independent workers, employees…) which are just starting to be regulated by States. It is these re
