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Covid-19 protein-protein interaction mapping – Cov2PIM
The identification of virus-virus and virus-host protein-protein interactions is a determinant element for the understanding of the mechanisms of replication and viral transmission. The knowledge of the molecular details of these protein interactions is a prerequisite for the discovery of new therap
Mitochondrial and metabolic evaluation of COVID-19 patients: new predictive factors and therapeutic targets – MIMETIC
Since last December, the coronavirus disease 2019 (COVID-19) affected more than 23 million people, causing more than 800,000 deaths. The clinical spectrum of COVID-19 goes from asymptomatic to multiorgan dysfunction requiring ICU (Intensive Care Unit) admission. Although a very few drugs might be pr
Immunostimulating molecules with a broad-spectrum antiviral activity: a proof of concept in non-human primate models – STING-2.0
Our therapeutic arsenal to treat virus-infected patients is extremely limited, and there is a critical need for broad-spectrum antiviral molecules that could be used against multiple viruses. Among possible strategies, the idea of molecules stimulating the innate immune response in host cells is of
Tracking trust and suspicion: Analysis of social media to assist public health responses to Covid-19 – TRACTRUST (Tracking Trust)
How to promote acceptance, uptake, and adherence to public health measures for COVID-19 prevention and control? What are the most effective ways to address the underlying drivers of fear, anxieties, rumours, stigma regarding, and how to improve public knowledge, awareness, and trust during the respo
eXplaining Competency and Autonomy development in Learning Environments – xCALE
With the advent of MOOCs, and the success of exercise-based platforms, large-scale online environments are becoming widespread, both in distant learning and in blended learning. Self-Regulated Learning (SRL) is known to have a good potential on autonomy development and on maintaining motivation fo
The Covid-19 North-South Death Transfer – Transfert de mortalité
The crisis generated by the coronavirus pandemic is unlike any other. Beyond the high mortality generated, it has plunged the world into uncertainty. In the first few months after the virus appeared, two strategies had emerged. The first was that the development of herd immunity was essential by all
Preclinical evaluation of a Potent Novel Human Cytomegalovirus Lead Drug Candidate – PRECYVIR
The current pandemic made it clear how important antiviral drugs are; not only against coronaviruses, but against many other families of viruses as well, which can lead to life-threatening conditions, especially in children. As French experts in antiviral drug research and development, the fight aga
Modulation of SARS-CoV-2 cell entry – COVENTRY
There is indeed an urgent need to develop treatments for COVID-19. COVID-19 pandemic is due to the SARS-CoV-2 coronavirus that infects human cells through binding of its spike S protein to cell receptors including the ACE2 protein. The entry of virus into the cell after binding to its receptor is st
REpresentations, PErceptions and Attitudes to the COVID-19 virus – REPEAT
The general proposal aims at investigating the representations, attitudes and reactions of public opinion in a context of the COVID-19 epidemic through a variety of countries differently exposed to the coronavirus. Contrary to conventional research projects, REPEAT has been conceived to be implement
SARS-CoV-2 endemization in wildlife of African rainforest following the spread of COVID-19 in the Republic of the Congo – SPILLBACK
Since December 2019, when reports of a new respiratory disease began to emerge from Wuhan, China, COVID-19 has spread worldwide, causing, causing 4 million confirmed cases and 250 000 deaths as of May 5, 2020. Recently, the outbreak has started to spread in Africa, raising major concerns for public
