JPcofuND 2. Understanding the mechanisms of non-pharmacological intervention

The present call is supported by 19-member countries: Australia, Belgium, Canada, Czech Republic, Denmark, Finland, France, Germany, Hungary, Italy, Latvia, Luxembourg, Netherlands, Norway, Poland, Slovakia, Spain, Switzerland and Turkey.

Proposals to this call must be hypothesis driven, ambitious, innovative, multi-disciplinary and multi-national, i.e. include research teams from at least three different countries that aim at understanding the biomedical, psychological and/or social mechanisms of non-pharmaceutical interventions in order to identify potential target sites for enhanced personalized interventions or a combination of pharmacological and non-pharmacological interventions.

Proposals submitted under this call may include, but are not limited to, the following types of research:

• Determining biomolecular and/or physical underpinnings of effects of non-pharmacological interventions;
   
• Examining the mechanisms of effective non-pharmacological interventions on the molecular and cellular level by applying cutting-edge technologies;
   
• Identification of the mechanisms of non-pharmacological interventions within the brain, using brain imaging, electrophysiology and other equivalent state of the art techniques;
   
• Identification of biological, psychological and social health markers and their associations to allow the identification of modifiable risk factors amenable to non-pharmacological interventions and better predict and monitor the effects of these interventions for future large-scale clinical studies;
   
• Elaborating modified concepts of non-pharmacological interventions with enhanced efficacy based on a deeper understanding of the mechanisms;
   
• Identification of potential drug-target sites for a combination of pharmacological and non-pharmacological interventions;
   
• Finding (individual) factors that predict response to interventions.