Circuit Electrophysiology of Anxiety – CEA
Anxiety disorders are the most prevalent mental disorders, with a lifetime prevalence of 15-30%. Current treatments remain however insufficient because of their lack of effectiveness. Several studies have highlighted that the amygdala is a key structure involved in anxiety notably through long-range connection with cortical structures. However, to date, the precise functional connectivity, neuronal activity and anatomy of these neuronal circuits mediating anxiety are largely unknown. To address these questions we will develop a translational strategy to evaluate whether amygdala networks activities are engaged in a functional coordination during physiological and pathological anxiety states in humans and rodents. This work will provide a better understanding of the neuronal mechanisms involved in anxiety and will allow the development of novel targeted therapeutical strategies.
Project coordination
cyril herry (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - UMR1215)
The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.
Partnership
INSERM UMR1215 INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - UMR1215
CERPAD Centre de Référence Régional des Pathologies Anxieuses et de la Dépression
INSERM UMR1215 INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - UMR1215
INSERM UMR1215 INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - UMR1215
Pôle Neurosciences Cliniques
IMN Institut des Maladies Neurodégénératives
Help of the ANR 846,335 euros
Beginning and duration of the scientific project:
September 2022
- 48 Months
