CE19 - Technologies pour la santé

Cocktail of sonosensitive droplets for BBB-opening and brain therapy. – Sono-Cocktail

Submission summary

The Central Nervous System (CNS) is a therapeutic target for many brain disorders including Amyotrophic Lateral Sclerosis (ALS) that is the focus of our project. Although a leakiness of the blood-brain barrier (BBB) is admitted during the progress of some brain pathologies, crossing the BBB remains a key challenge to overcome in the treatment of most CNS diseases including ALS. Our project consists of creating a tool causing the transient opening of the BBB and then the controlled release of a drug in the CNS. To do so, we intend to use a smart US-triggered formulation composed of a cocktail of large and small perfluorocarbon droplets sensitive to different acoustic sequences. Large droplets will transiently open the BBB while small droplets will ensure the drug delivery and controlled release in the brain compartment.

Project coordination

Nicolas TAULIER (Sorbonne Université)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.


iBrain Institut national de la sante et de la recherche medicale
LPENS Laboratoire de physique de l'ENS
LIB Sorbonne Université
UPRI Unité Propre de Recherche et d’Innovation

Help of the ANR 791,536 euros
Beginning and duration of the scientific project: - 48 Months

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