Pan-Cancer Imaging and Killing Strategy – PanCaiKS

Currently, standard cancer treatment includes surgery, external radiotherapy, and chemotherapy and / or immunotherapy. However, despite all the progress made in recent decades, there are still serious clinical situations offering very few or no therapeutic options to patients, leaving them with a survival limited to a few months in the case of cancers associated with a poor prognosis. There is therefore an urgent need for new treatment lines and, from this perspective, vectorized internal radiotherapy seems promising. It delivers a toxic dose of radioactivity directly to tumor cells while preserving healthy tissue. This requires the specific targeting of tumor cells: among the possible vectors, peptides are powerful tools since they are chemically accessible and can be easily modified to construct radiotherapies specific to a cell target. The PanCAIKS project aims to develop targeted radiotherapy agents based on peptides directed specifically to an original receptor (Peptide Receptor RadioTherapy, PRRT) to treat cancers with a poor prognosis (for example, pancreatic, liver and triple breast tumors. negative or gliomas.