Impulse control disorders (ICDs), for example gambling behaviors, hypersexuality or compulsive eating, are characterized by urges and excessive and uncontrolled behaviors, which ultimately can become harmful. Although ICDs are on the rise and a growing socio-economic burden, the underlying molecular and cellular mechanisms, as well as neural circuits remain poorly understood. With the use of translational and state-of-the art conditional, transcriptomic and electrophysiological approaches, we propose here to 1) elucidate the mechanistic underpinnings of ICDs in a rodent model of impulsive behaviors and 2) identify and validating new biomarker(s) for ICDs in patients treated with dopaminergic agonists. This multidisciplinary project, which includes 5 partners, is likely to provide new tools and therapeutic approaches for a better management of ICDs.
Monsieur Sebastien Carnicella (GRENOBLE INSTITUT DES NEUROSCIENCES (GIN))
The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.
ICM Institut du cerveau et de la moelle épinière
U 1216 GRENOBLE INSTITUT DES NEUROSCIENCES (GIN)
INMED Institut de Neurobiologie de la Méditerranée
IGF Institut de génomique fonctionnelle
NET Neuroépidémiologie Tropicale
Help of the ANR 679,456 euros
Beginning and duration of the scientific project: September 2021 - 48 Months