Adjuvant-Protein surface Interaction in vaccine formulations: an NMR perspective – API-NMR
Aluminum-hydroxide-based adjuvants can absorb protein antigens from an aqueous solution and it is these adjuvants, as well as those based on aluminum phosphate, that are now widely used in vaccine formulation because of their immunostimulant behavior. The limited data in the literature show that the immune response of a vaccine formulation is related to (i) the structure of the adjuvant, (ii) the surface properties and (iii) the nature of the interaction with antigens and highlight the lack of thorough understanding of the molecular forces driving absorption/release. The objective of this project is to characterize protein/adjuvant interactions at a fundamental level using a model antigen and implementing state-of-the-art solid-state NMR approaches to describe the protein-adjuvant interface with atomic resolution.
Monsieur Pierre Florian (Conditions Extrêmes et Matériaux : Haute température et Irradiation)
The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.
CEMHTI Conditions Extrêmes et Matériaux : Haute température et Irradiation
CBMN INSTITUT DE CHIMIE ET DE BIOLOGIE DES MEMBRANES ET DES NANOOBJETS
CRMN Centre de Résonance Magnétique Nucléaire à très hauts champs de Lyon
Help of the ANR 521,920 euros
Beginning and duration of the scientific project: May 2022 - 36 Months