Spectroscopic LCOCT for cancer diagnosis improvement in dermatology – Spec-LCOCT

Line-field Confocal Optical Coherence Tomography (LC-OCT) is an imaging technique invented by A. Dubois (project coordinator) and developed by DAMAE Medical for non-invasive in situ skin cancer diagnosis by providing a comprehensive cellular mapping of skin lesions based on morphological information. The core of this project is the implementation of several spectroscopic modalities in LC-OCT, based on Raman scattering, fluorescence emission and diffuse reflectance to provide additional information on the local biochemistry of the skin tissue. The combination of spectroscopic measurements with high-resolution morphological information should significantly improve the skin cancer diagnosis accuracy. Combining high spatial resolution (1 µm), deep penetration (~ 1 mm), and molecular contrast in a handheld device should revolutionize skin cancer management and reduce lifetime healthcare costs.