Smart Bone Organoid Bioreactor – SMART_BONE_ORGANOID

In the last decade, the development of organoids has generated real enthusiasm, allowing the study of new treatments and the implementation of a personalized medicine approach while reducing experiments on animals. The generation of bone organoids from human mesenchymal stem cells capable of mimicking certain bone functionalities requires exposing the cells to physiologically relevant conditions. The proposed project aims to develop a smart bone bioreactor capable, for the first time, of measuring and adapting, in a dynamic and controlled manner, the mechanical stress, oxygen tension and nutrient supply to the cells throughout the entire genesis of the bone organoid. This project will rely on the consortium's leading-edge expertise in the field of bone and in particular on the development of a pre-existing bioreactor. The ultimate validation phase will be an efficient treatment against bone fragility on the organoid generated from the Smart Bone Bioreactor.