Targeting cellular MEchanisms of altered regeneration for ALcoholic hepatitis precision medicine. – MEdicAL

Alcoholic hepatitis (AH) is the most severe form of alcohol-associated liver disease (ALD). The pathogenesis of this life-threatening disease is complex and poorly understood due to the lack of animal models, while translational studies suffer from limited access to human liver samples. Despite its undeniable economical and health burden affecting both women and men, ALD has received very limited attention from health policy makers, pharmaceutical companies, and funding agencies. The major consequence is the very limited therapeutic arsenal, particularly for AH where the tools for the patient’s management have not evolved substantially over the last decades. Based on unique liver samples collected by our group, we have demonstrated a profound alteration of hepatocyte regeneration in AH liver. The proposed project is a translational study aiming at dissecting the cellular and molecular mechanisms implicated in the altered liver regeneration of patients with AH, in order to develop innovative therapeutic strategies.