CE11 - Caractérisation des structures et relations structure-fonctions des macromolécules biologiques

Unraveling the role of AURKA on mitochondria cristae structure by super-resolution microscopy and FRET – MACSUP

Submission summary

Mitochondria, the powerhouse of the cell, are double-membrane organelles. While the outer membrane encloses mitochondria, the inner one is folded into invaginations called cristae. Long considered static structures, recent data revealed that cristae are rather dynamic. However, the molecular players regulating cristae structure are only starting to be revealed. By combining genetically-encoded FRET biosensors and super-resolution microscopy in live human cells, we will determine: (i) novel molecular players acting on cristae structure; (ii) how these novel partners activate at cristae, and (iii) how the regulation of cristae structure is integrated with other mitochondrial functions. Our results will reveal how the cristae structure is dynamically maintained in living cells, and will pave the way to therapeutic perspectives for diseases where the cristae structure is altered. Last, the support by the ANR will boost my early-stage career and allow me to set up my independent lab.

Project coordination

Giulia Bertolin (INSTITUT DE GENETIQUE ET DEVELOPPEMENT DE RENNES)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partnership

IGDR INSTITUT DE GENETIQUE ET DEVELOPPEMENT DE RENNES

Help of the ANR 299,834 euros
Beginning and duration of the scientific project: January 2022 - 48 Months

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