CE06 - Polymères, composites, physique et chimie de la matière molle, procédés

Dissociation mechanisms of complexes containing nucleic acids for gene release – DIMECO

Submission summary

Natural or synthetic polycations and lipids, are used in nucleic acid therapeutics, such as the mRNA vaccine field and gene therapy, as vectors that interact electrostatically with nucleic acids, condense them into nanoparticles, protect them and control their entry and release into cells. While the literature on the formation of complex particles is very well documented, much less studies have focused on the physical chemistry behind the endosomal escape disassembly, in particular in physicochemical conditions found in endosomal compartments and in an intracellular environment. This project aims to study the dissociation mechanisms of complexes containing nucleic acids (DNA, siRNA, mRNA) and either natural/synthetic polycations or cationic lipids in conditions found in extra- and intracellular medium: in presence of biological polyanions, osmolytes and lipid membranes. This knowledge will provide the basis for future improvement of the efficacy of nonviral vectors for gene deliver

Project coordination

Lourdes Monica Bravo Anaya (Institut des sciences chimiques de Rennes)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.


ISCR Institut des sciences chimiques de Rennes

Help of the ANR 226,332 euros
Beginning and duration of the scientific project: - 48 Months

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