Household Transmission Dynamics of Multidrug Resistant Enterobacteriaceae – HOME
To date, dynamics of transmission of Multi-Drug Resistant Enterobacteriaceae (MDR-E, including Extended-Spectrum Beta-Lactamase and Carbapenemase-Producing Enterobacteriaceae) have been mainly studied in hospitals. Several studies suggest, however, that MDR-E spread widely in the community through human-to-human transmission. This multidisciplinary project will, using microbiology, epidemiology and mathematical modeling techniques: 1) estimate transmission rates of MDR-E from an index case to his/her household members, and 2) identify the epidemiological and microbiological factors associated with transmission (genomic characteristics of strains, relative faecal abundance, influence of the microbiota). Knowledge gained will inform decision makers and scientists with respect to the impact of control strategies to specifically control the spread of multidrug-resistant microorganisms in the community.
Project coordination
Solen Kernéis (Institut Pasteur - Unité Epidémiologie et modélisation de la résistance aux antimicrobiens)
The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.
Partner
DMU APHP.Nord : Biologie et Génomique médicales - Université de Paris
IP - EMEA Institut Pasteur - Unité Epidémiologie et modélisation de la résistance aux antimicrobiens
CESP CENTRE DE RECHERCHE EN ÉPIDÉMIOLOGIE ET SANTÉ DES POPULATIONS
IAME Infection, Antimicrobials, Modelling, Evolution
PRISME DMU APHP.Nord : Pharmacies, Produits de Santé, Recherche clinique, Information médicale, Santé Publique hospitalière, Méthodes en évaluation, Epidémiologie
Help of the ANR 598,977 euros
Beginning and duration of the scientific project:
March 2021
- 36 Months
