CE20 - Biologie des animaux, des organismes photosynthétiques et des microorganismes

Genome and epigenome dynamics of random and targeted DNA damages – RanTarDam

Submission summary

Plants evolved sophisticated mechanisms to cope with environmental stresses that affect genome integrity and interfere with developmental programs. In particular, it is crucial to understand how genetic and epigenetic mechanisms cooperate with DNA repair to activate appropriate adaptive responses that efficiently protect the genome against deleterious damages. The aim of the RanTarDAm project is to understand at the molecular level how the plant genome-epigenome-transcriptome deal with random (genotoxic stress) and targeted (CRISPR/Cas9) DNA damages. The combined expertise of the consortium in DNA repair-RNA biology together with promising preliminary data provide an unique opportunity to decipher the interplays between mechanisms involved in the maintenance of (epi)genome and transcriptome integrities upon random and targeted DNA damages. Our findings are likely to apply to breeding programs as well as to other organisms, at least conceptually, including potentially to vertebrates.

Project coordination

Jean MOLINIER (Institut de biologie moléculaire des plantes (UPR 2357))

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

IBMP Institut de biologie moléculaire des plantes (UPR 2357)
IJPB INRAE Institut Jean-Pierre BOURGIN

Help of the ANR 451,263 euros
Beginning and duration of the scientific project: December 2020 - 48 Months

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