CE20 - Biologie des animaux, des organismes photosynthétiques et des microorganismes

Cryo-EM tridimentional structure of insect Odorant Receptors: towards new semiochemicals for pest biocontrol – CryOR

Submission summary

In the context of the developpment of pest insect biocontrol, odorant receptor proteins are seen as interesting targets to modify insect odorant-guided behaviors. However, the lack of similarity of these receptors with any known membrane proteins make their study difficult at the molecular level: their tridimensional modelling is impossible; the odorant-binding site cannot be determined. The present project thus proposes to use the more recent developments of atomic resolution Cryo-electron microscopy to decipher the first tridimensional structures of sex pheromone receptors from an invasive polyphagous pest moth, the leafworm Spodoptera littoralis. The obtained structures, refined via directed mutagenesis, will serve as matrix to design agonists and/or antagonists to sex pheromones, whose potential in crop protection will be tested on the moth neurons and in fine the moth behaviour.

Project coordination

Emmanuelle Jacquin-Joly (Institut d'écologie et des sciences de l'environnement de Paris)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.


IEES-Paris Institut d'écologie et des sciences de l'environnement de Paris
AFMB Architecture et fonction des macromolécules biologiques

Help of the ANR 461,114 euros
Beginning and duration of the scientific project: January 2021 - 36 Months

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