CE12 - Génétique, génomique et ARN

Chromatin organization based mechanisms of TE silencing – COMETES

Submission summary

Transposable elements (TEs) constitute a large portion of eukaryotic genomes. Because of their mobility, they are potential threats for the host genome. One big challenge in biology is to determine how the chromatin silencing machinery establishes and maintains TE silencing. Based on preliminary data from the consortium, demonstrating a new role for 5 chromatin factors in TE transcriptional silencing in Drosophila, we plan to 1) investigate the mechanisms by which these chromatin factors silence TEs in Drosophila ovarian cells; 2) study their impact on TE mobilization and genome stability in oogenesis; 3) identify chromatin factors implicated in TE silencing in non gonadal tissues. The goal of this study is to identify the mechanisms by which chromatin regulates TEs. This study will aid our understanding of the role of TE regulation in development and how their de-regulation leads to sterility and diseases such as cancer or neurodegeneration.

Project coordination

Luisa DI STEFANO (Unité de biologie moléculaire, cellulaire et du développement)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

MCD Unité de biologie moléculaire, cellulaire et du développement
IGH Institut de Génétique Humaine

Help of the ANR 557,919 euros
Beginning and duration of the scientific project: January 2021 - 48 Months

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