CE12 - Génétique, génomique et ARN

Stress-induced phase separation in RNA expression control, organismal fitness and adaptive evolution – RNADAPT

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Submission summary

Despite being universal across eukaryotic as well as prokaryotic taxa, the mechanistic and adaptive significance of RNA phase separations remains unclear. Based on our preliminary data showing that RNA phase separation in the C. elegans germline displays extensive environmental and evolutionary variability, we will (1) test if RNA phase separation fine-tunes RNA expression in response to temperature stress; (2) test if natural genetic variation in C. elegans RNA phase separation and its temperature sensitivity is consistent with adaptation to different thermal niches; (3) map and molecular characterize natural variation in RNA phase separation across different wild isolates; (4) to test if and how RNA phase separation improves organismal fitness. RNA phase separation seems to be a central mechanism regulating RNA expression to maintain cellular integrity in adverse environments. Our interdisciplinary project is among the first to test this hypothesis in a metazoan organism.

Project coordination

Christian BRAENDLE (Institut de Biologie Valrose)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

iBV Institut de biologie de Valrose
iBV Institut de Biologie Valrose

Help of the ANR 560,952 euros
Beginning and duration of the scientific project: November 2020 - 48 Months

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