CE07 - Chimie moléculaire

Catalysis in Cells using Light and Supramolecular Metallic Scaffolds – CataCLiSMS

Submission summary

The CataCLiSMS project aims at developing photoactivatable reactions in cellulo by using a family of water-soluble copper complexes based on modified cyclodextrins. More particularly, light-induced copper-catalyzed transformations of thiols will be studied in water then in biological media, by using specifically designed biocompatible and light-activatable copper complexes. A particularly relevant biological thiol target is glutathione (GSH), whose regulation could be exploited for the treatment of diseases. Therefore, the project also aims at exploring light-induced copper-catalysis to induce cell/bacteria death through GSH oxidation, which will disrupt the redox imbalance of the cell. In this setting, light is a traceless and benign way for targeting specific cells, bacteria or tissues, opening new avenues in the treatment of different types of diseases such as Alzheimer, Parkinson, autoimmune diseases, diabetes or cancer.

Project coordination

Sylvain Roland (Institut Parisien de Chimie Moléculaire)

The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.

Partner

IPCM Institut Parisien de Chimie Moléculaire
i-CLeHS Institute of Chemistry for Life and Health Sciences

Help of the ANR 429,192 euros
Beginning and duration of the scientific project: December 2020 - 48 Months

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