Artificial Intelligence to reach the far side of chromosomes – Apollo
The 3D structure of chromosomes is finely organized to ensure major biological functions such as replication and transcriptional
regulation. To study it in detail, so-called contact techniques (3C, Hi-C) are developed in parallel with microscopy, which trap
fragments of chromosomes in physical contact and allow the average 3D structure of a chromosome to be deduced.
These techniques generate millions of pairs of small sequences (~ 50 nucleotides), a certain proportion of which cannot be located
directly due to their repetition in the sequence of the reference genome (several alignments are possible).
We propose the project called Apollo, which aims to use numerical simulation, machine learning and statistical methods to predict
the positions of these currently missing repeating sequences and thus reveal the hidden side of chromosomes.
Project coordination
Axel Cournac (INSTITUT PASTEUR)
The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.
Partner
IP INSTITUT PASTEUR
Help of the ANR 235,854 euros
Beginning and duration of the scientific project:
January 2020
- 42 Months